Reaction Details Report a problem with these data
Target
Bcl-2-like protein 2
Ligand
BDBM50024671
Substrate
n/a
Meas. Tech.
ChEMBL_422737 (CHEMBL909833)
Ki
59320±n/a nM
Citation
 Doshi, JM; Tian, D; Xing, C Structure-activity relationship studies of ethyl 2-amino-6-bromo-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate (HA 14-1), an antagonist for antiapoptotic Bcl-2 proteins to overcome drug resistance in cancer. J Med Chem 49:7731-9 (2006) [PubMed]  Article 
Target
Name:
Bcl-2-like protein 2
Synonyms:
Apoptosis regulator Bcl-W | B2CL2_HUMAN | BCL-W | BCL2L2 | BCLW | Bcl-2-like protein 2 | Bcl2-L-2 | KIAA0271
Type:
Protein
Mol. Mass.:
20742.61
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
193
Sequence:
MATPASAPDTRALVADFVGYKLRQKGYVCGAGPGEGPAADPLHQAMRAAGDEFETRFRRTFSDLAAQLHVTPGSAQQRFTQVSDELFQGGPNWGRLVAFFVFGAALCAESVNKEMEPLVGQVQEWMVAYLETQLADWIHSSGGWAEFTALYGDGALEEARRLREGNWASVRTVLTGAVALGALVTVGAFFASK
  
Inhibitor
Name:
BDBM50024671
Synonyms:
CHEMBL2374449
Type:
Small organic molecule
Emp. Form.:
C23H32O2S
Mol. Mass.:
372.564
SMILES:
CCSCCCCC(c1ccc(O)cc1)C(C)(CC)c1ccc(O)cc1
Structure:
Search PDB for entries with ligand similarity: