Reaction Details Report a problem with these data
Target
Deoxynucleoside kinase
Ligand
BDBM50118490
Substrate
n/a
Meas. Tech.
ChEMBL_422918 (CHEMBL908770)
IC50
3300±n/a nM
Citation
Hernandez, AI; Familiar, O; Negri, A; Rodríguez-Barrios, F; Gago, F; Karlsson, A; Camarasa, MJ; Balzarini, J; Pérez-Pérez, MJ N1-substituted thymine derivatives as mitochondrial thymidine kinase (TK-2) inhibitors. J Med Chem 49:7766-73 (2006) [PubMed] Article
More Info.:
Target
Name:
Deoxynucleoside kinase
Synonyms:
DNK_DROME | Deoxyribonucleoside kinase | Dm-dNK | Multispecific deoxynucleoside kinase | dnk
Type:
PROTEIN
Mol. Mass.:
29092.93
Organism:
Drosophila melanogaster
Description:
ChEMBL_627484
Residue:
250
Sequence:
MAEAASCARKGTKYAEGTQPFTVLIEGNIGSGKTTYLNHFEKYKNDICLLTEPVEKWRNVNGVNLLELMYKDPKKWAMPFQSYVTLTMLQSHTAPTNKKLKIMERSIFSARYCFVENMRRNGSLEQGMYNTLEEWYKFIEESIHVQADLIIYLRTSPEVAYERIRQRARSEESCVPLKYLQELHELHEDWLIHQRRPQSCKVLVLDADLNLENIGTEYQRSESSIFDAISSNQQPSPVLVSPSKRQRVAR
Inhibitor
Name:
BDBM50118490
Synonyms:
1-[(Z)-4-(triphenylmethoxy)-2-butenyl]thymine | 5-Methyl-1-(4-trityloxy-but-2-enyl)-1H-pyrimidine-2,4-dione | CHEMBL101135
Type:
Small organic molecule
Emp. Form.:
C28H26N2O3
Mol. Mass.:
438.5176
SMILES:
Cc1cn(C\C=C/COC(c2ccccc2)(c2ccccc2)c2ccccc2)c(=O)[nH]c1=O