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Target
Carboxypeptidase N catalytic chain
Ligand
BDBM50201434
Substrate
n/a
Meas. Tech.
ChEMBL_453906 (CHEMBL885910)
IC50
1750±n/a nM
Citation
 Islam, I; Bryant, J; May, K; Mohan, R; Yuan, S; Kent, L; Morser, J; Zhao, L; Vergona, R; White, K; Adler, M; Whitlow, M; Buckman, BO 3-Mercaptopropionic acids as efficacious inhibitors of activated thrombin activatable fibrinolysis inhibitor (TAFIa). Bioorg Med Chem Lett 17:1349-54 (2007) [PubMed]  Article 
Target
Name:
Carboxypeptidase N catalytic chain
Synonyms:
ACBP | Anaphylatoxin inactivator | Arginine carboxypeptidase | CBPN_HUMAN | CPN | CPN1 | Carboxypeptidase N catalytic chain | Carboxypeptidase N polypeptide 1 | Carboxypeptidase N small subunit | Carboxypeptidase N, catalytic subunit | Kininase-1 | Lysine carboxypeptidase | Plasma carboxypeptidase B | SCPN | Serum carboxypeptidase N
Type:
PROTEIN
Mol. Mass.:
52293.66
Organism:
Homo sapiens (Human)
Description:
ChEMBL_1496379
Residue:
458
Sequence:
MSDLLSVFLHLLLLFKLVAPVTFRHHRYDDLVRTLYKVQNECPGITRVYSIGRSVEGRHLYVLEFSDHPGIHEPLEPEVKYVGNMHGNEALGRELMLQLSEFLCEEFRNRNQRIVQLIQDTRIHILPSMNPDGYEVAAAQGPNKPGYLVGRNNANGVDLNRNFPDLNTYIYYNEKYGGPNHHLPLPDNWKSQVEPETRAVIRWMHSFNFVLSANLHGGAVVANYPYDKSFEHRVRGVRRTASTPTPDDKLFQKLAKVYSYAHGWMFQGWNCGDYFPDGITNGASWYSLSKGMQDFNYLHTNCFEITLELSCDKFPPEEELQREWLGNREALIQFLEQVHQGIKGMVLDENYNNLANAVISVSGINHDVTSGDHGDYFRLLLPGIYTVSATAPGYDPETVTVTVGPAEPTLVNFHLKRSIPQVSPVRRAPSRRHGVRAKVQPQARKKEMEMRQLQRGPA
  
Inhibitor
Name:
BDBM50201434
Synonyms:
3-mercapto-2-(piperidin-3-yl)propanoic acid | CHEMBL245591
Type:
Small organic molecule
Emp. Form.:
C8H15NO2S
Mol. Mass.:
189.275
SMILES:
OC(=O)C(CS)C1CCCNC1 |w:3.3,6.6|
Structure:
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