Reaction Details Report a problem with these data
Target
Angiotensinogen
Ligand
BDBM50213195
Substrate
n/a
Meas. Tech.
ChEMBL_2303161
IC50
>1000±n/a nM
Citation
 Alagarsamy, V; Chitra, K; Saravanan, G; Solomon, VR; Sulthana, MT; Narendhar, B An overview of quinazolines: Pharmacological significance and recent developments. Eur J Med Chem 151:628-685 (2018) [PubMed] 
Target
Name:
Angiotensinogen
Synonyms:
ANGT_RAT | Agt | Angiotensin | Serpina8
Type:
Enzyme Catalytic Domain
Mol. Mass.:
51974.87
Organism:
RAT
Description:
Angiotensin 0 RAT::P01015
Residue:
477
Sequence:
MTPTGAGLKATIFCILTWVSLTAGDRVYIHPFHLLYYSKSTCAQLENPSVETLPEPTFEPVPIQAKTSPVDEKTLRDKLVLATEKLEAEDRQRAAQVAMIANFMGFRMYKMLSEARGVASGAVLSPPALFGTLVSFYLGSLDPTASQLQVLLGVPVKEGDCTSRLDGHKVLTALQAVQGLLVTQGGSSSQTPLLQSTVVGLFTAPGLRLKQPFVESLGPFTPAIFPRSLDLSTDPVLAAQKINRFVQAVTGWKMNLPLEGVSTDSTLFFNTYVHFQGKMRGFSQLTGLHEFWVDNSTSVSVPMLSGTGNFQHWSDAQNNFSVTRVPLGESVTLLLIQPQCASDLDRVEVLVFQHDFLTWIKNPPPRAIRLTLPQLEIRGSYNLQDLLAQAKLSTLLGAEANLGKMGDTNPRVGEVLNSILLELQAGEEEQPTESAQQPGSPEVLDVTLSSPFLFAIYERDSGALHFLGRVDNPQNVV
  
Inhibitor
Name:
BDBM50213195
Synonyms:
CHEMBL14951
Type:
Small organic molecule
Emp. Form.:
C28H28N6O2
Mol. Mass.:
480.5609
SMILES:
CCCCc1nc2ccc(COC)cc2c(=O)n1Cc1ccc(cc1)-c1ccccc1-c1nn[nH]n1
Structure:
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