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Target
Adenosine receptor A2a
Ligand
BDBM50202785
Substrate
n/a
Meas. Tech.
ChEMBL_454055 (CHEMBL903246)
Ki
3.7±n/a nM
Citation
 Silverman, LS; Caldwell, JP; Greenlee, WJ; Kiselgof, E; Matasi, JJ; Tulshian, DB; Arik, L; Foster, C; Bertorelli, R; Monopoli, A; Ongini, E 3H-[1,2,4]-Triazolo[5,1-i]purin-5-amine derivatives as adenosine A2A antagonists. Bioorg Med Chem Lett 17:1659-62 (2007) [PubMed]  Article 
Target
Name:
Adenosine receptor A2a
Synonyms:
A2A adenosine receptor (hA2A) | AA2AR_HUMAN | ADENOSINE A2 | ADENOSINE A2a | ADORA2 | ADORA2A | Adenosine A2A receptor (A2AAR)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
44716.46
Organism:
Homo sapiens (Human)
Description:
P29274
Residue:
412
Sequence:
MPIMGSSVYITVELAIAVLAILGNVLVCWAVWLNSNLQNVTNYFVVSLAAADIAVGVLAIPFAITISTGFCAACHGCLFIACFVLVLTQSSIFSLLAIAIDRYIAIRIPLRYNGLVTGTRAKGIIAICWVLSFAIGLTPMLGWNNCGQPKEGKNHSQGCGEGQVACLFEDVVPMNYMVYFNFFACVLVPLLLMLGVYLRIFLAARRQLKQMESQPLPGERARSTLQKEVHAAKSLAIIVGLFALCWLPLHIINCFTFFCPDCSHAPLWLMYLAIVLSHTNSVVNPFIYAYRIREFRQTFRKIIRSHVLRQQEPFKAAGTSARVLAAHGSDGEQVSLRLNGHPPGVWANGSAPHPERRPNGYALGLVSGGSAQESQGNTGLPDVELLSHELKGVCPEPPGLDDPLAQDGAGVS
  
Inhibitor
Name:
BDBM50202785
Synonyms:
3-(2-(4-(4-(2-methoxyethoxy)phenyl)piperazin-1-yl)ethyl)-8-phenyl-3H-[1,2,4]triazolo[1,5-g]purin-5-amine | CHEMBL246468
Type:
Small organic molecule
Emp. Form.:
C27H31N9O2
Mol. Mass.:
513.5941
SMILES:
COCCOc1ccc(cc1)N1CCN(CCn2cnc3c4nc(nn4c(N)nc23)-c2ccccc2)CC1
Structure:
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