Reaction Details Report a problem with these data
Target
Malonyl-CoA decarboxylase, mitochondrial
Ligand
BDBM50202813
Substrate
n/a
Meas. Tech.
ChEMBL_454062 (CHEMBL903253)
IC50
4900±n/a nM
Citation
 Wallace, DM; Haramura, M; Cheng, JF; Arrhenius, T; Nadzan, AM Novel trifluoroacetophenone derivatives as malonyl-CoA decarboxylase inhibitors. Bioorg Med Chem Lett 17:1127-30 (2007) [PubMed]  Article 
Target
Name:
Malonyl-CoA decarboxylase, mitochondrial
Synonyms:
DCMC_HUMAN | MLYCD | Malonyl-CoA decarboxylase
Type:
PROTEIN
Mol. Mass.:
55018.37
Organism:
Homo sapiens (Human)
Description:
ChEMBL_665404
Residue:
493
Sequence:
MRGFGPGLTARRLLPLRLPPRPPGPRLASGQAAGALERAMDELLRRAVPPTPAYELREKTPAPAEGQCADFVSFYGGLAETAQRAELLGRLARGFGVDHGQVAEQSAGVLHLRQQQREAAVLLQAEDRLRYALVPRYRGLFHHISKLDGGVRFLVQLRADLLEAQALKLVEGPDVREMNGVLKGMLSEWFSSGFLNLERVTWHSPCEVLQKISEAEAVHPVKNWMDMKRRVGPYRRCYFFSHCSTPGEPLVVLHVALTGDISSNIQAIVKEHPPSETEEKNKITAAIFYSISLTQQGLQGVELGTFLIKRVVKELQREFPHLGVFSSLSPIPGFTKWLLGLLNSQTKEHGRNELFTDSECKEISEITGGPINETLKLLLSSSEWVQSEKLVRALQTPLMRLCAWYLYGEKHRGYALNPVANFHLQNGAVLWRINWMADVSLRGITGSCGLMANYRYFLEETGPNSTSYLGSKIIKASEQVLSLVAQFQKNSKL
  
Inhibitor
Name:
BDBM50202813
Synonyms:
4-cyano-N-(4-(2,2,2-trifluoroacetyl)phenyl)benzamide | CHEMBL241724
Type:
Small organic molecule
Emp. Form.:
C16H9F3N2O2
Mol. Mass.:
318.2501
SMILES:
FC(F)(F)C(=O)c1ccc(NC(=O)c2ccc(cc2)C#N)cc1
Structure:
Search PDB for entries with ligand similarity: