Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM21278
Substrate
n/a
Meas. Tech.
ChEMBL_438315 (CHEMBL887423)
IC50
6.1±n/a nM
Citation
 Armstrong, HE; Galka, A; Lin, LS; Lanza, TJ; Jewell, JP; Shah, SK; Guthikonda, R; Truong, Q; Chang, LL; Quaker, G; Colandrea, VJ; Tong, X; Wang, J; Xu, S; Fong, TM; Shen, CP; Lao, J; Chen, J; Shearman, LP; Stribling, DS; Rosko, K; Strack, A; Ha, S; Van der Ploeg, L; Goulet, MT; Hagmann, WK Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists. Bioorg Med Chem Lett 17:2184-7 (2007) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
CANN6 | CANNABINOID CB1 | CB-R | CB1 | CNR | CNR1 | CNR1_HUMAN | Cannabinoid CB1 receptor | Cannabinoid receptor | Cannabinoid receptor 1 (CB1) | Cannabinoid receptor 1 (brain)
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
52868.96
Organism:
Homo sapiens (Human)
Description:
P21554
Residue:
472
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNPQLVPADQVNITEFYNKSLSSFKENEENIQCGENFMDIECFMVLNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFIDFHVFHRKDSRNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCEKLQSVCSDIFPHIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNAASVHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM21278
Synonyms:
5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-N-(piperidin-1-yl)-1H-pyrazole-3-carboxamide | Acomplia | CHEMBL111 | CHEMBL558598 | RIMONABANT HYDROCHLORIDE | Rimonabant | SR 141716A | SR141716 | SR141716A | [3H]Rimonabant | [3H]SR141716A
Type:
Small organic molecule
Emp. Form.:
C22H21Cl3N4O
Mol. Mass.:
463.787
SMILES:
Cc1c(nn(c1-c1ccc(Cl)cc1)-c1ccc(Cl)cc1Cl)C(=O)NN1CCCCC1
Structure:
Search PDB for entries with ligand similarity: