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Target
Beta-1 adrenergic receptor
Ligand
BDBM50205507
Substrate
n/a
Meas. Tech.
ChEMBL_435751 (CHEMBL920282)
Ki
61±n/a nM
Citation
 Dallanoce, C; Frigerio, F; De Amici, M; Dorsch, S; Klotz, KN; De Micheli, C Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes. Bioorg Med Chem 15:2533-43 (2007) [PubMed]  Article 
Target
Name:
Beta-1 adrenergic receptor
Synonyms:
ADRB1 | ADRB1R | ADRB1_HUMAN | B1AR | Beta-1 adrenoceptor | Beta-1 adrenoreceptor | adrenergic Beta1
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
51338.40
Organism:
Homo sapiens (Human)
Description:
P08588
Residue:
477
Sequence:
MGAGVLVLGASEPGNLSSAAPLPDGAATAARLLVPASPPASLLPPASESPEPLSQQWTAGMGLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATIVVWGRWEYGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVSFLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQVKKIDSCERRFLGGPARPPSPSPSPVPAPAPPPGPPRPAAAAATAPLANGRAGKRRPSRLVALREQKALKTLGIIMGVFTLCWLPFFLANVVKAFHRELVPDRLFVFFNWLGYANSAFNPIIYCRSPDFRKAFQGLLCCARRAARRRHATHGDRPRASGCLARPGPPPSPGAASDDDDDDVVGATPPARLLEPWAGCNGGAAADSDSSLDEPCRPGFASESKV
  
Inhibitor
Name:
BDBM50205507
Synonyms:
(S,R)-(-)-{4-[2-{[2-(3-bromoisoxazol-5-yl)-2-hydroxyethyl]-amino}propyl]phenoxy}acetic acid | CHEMBL387851
Type:
Small organic molecule
Emp. Form.:
C16H19BrN2O5
Mol. Mass.:
399.236
SMILES:
C[C@H](Cc1ccc(OCC(O)=O)cc1)NC[C@H](O)c1cc(Br)no1
Structure:
Search PDB for entries with ligand similarity: