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Target
Beta-3 adrenergic receptor
Ligand
BDBM50205506
Substrate
n/a
Meas. Tech.
ChEMBL_435753 (CHEMBL920284)
Ki
2485±n/a nM
Citation
 Dallanoce, C; Frigerio, F; De Amici, M; Dorsch, S; Klotz, KN; De Micheli, C Novel chiral isoxazole derivatives: synthesis and pharmacological characterization at human beta-adrenergic receptor subtypes. Bioorg Med Chem 15:2533-43 (2007) [PubMed]  Article 
Target
Name:
Beta-3 adrenergic receptor
Synonyms:
ADRB3 | ADRB3R | ADRB3_HUMAN | B3AR | Beta-2 adrenergic receptor and beta-3 adrenergic receptor | Beta-3 adrenoceptor | Beta-3 adrenoreceptor | adrenergic Beta3
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
43534.88
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
408
Sequence:
MAPWPHENSSLAPWPDLPTLAPNTANTSGLPGVPWEAALAGALLALAVLATVGGNLLVIVAIAWTPRLQTMTNVFVTSLAAADLVMGLLVVPPAATLALTGHWPLGATGCELWTSVDVLCVTASIETLCALAVDRYLAVTNPLRYGALVTKRCARTAVVLVWVVSAAVSFAPIMSQWWRVGADAEAQRCHSNPRCCAFASNMPYVLLSSSVSFYLPLLVMLFVYARVFVVATRQLRLLRGELGRFPPEESPPAPSRSLAPAPVGTCAPPEGVPACGRRPARLLPLREHRALCTLGLIMGTFTLCWLPFFLANVLRALGGPSLVPGPAFLALNWLGYANSAFNPLIYCRSPDFRSAFRRLLCRCGRRLPPEPCAAARPALFPSGVPAARSSPAQPRLCQRLDGASWGVS
  
Inhibitor
Name:
BDBM50205506
Synonyms:
(S,R)-(-)-1-(3-bromoisoxazol-5-yl)-2-{[2-(4-butoxyphenyl)-1-methylethyl]amino}ethanol | CHEMBL226349
Type:
Small organic molecule
Emp. Form.:
C18H25BrN2O3
Mol. Mass.:
397.307
SMILES:
CCCCOc1ccc(C[C@@H](C)NC[C@H](O)c2cc(Br)no2)cc1
Structure:
Search PDB for entries with ligand similarity: