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Target
Cytosolic phospholipase A2
Ligand
BDBM50149408
Substrate
n/a
Meas. Tech.
ChEMBL_428330 (CHEMBL917108)
IC50
4400±n/a nM
Citation
 Lee, KL; Foley, MA; Chen, L; Behnke, ML; Lovering, FE; Kirincich, SJ; Wang, W; Shim, J; Tam, S; Shen, MW; Khor, S; Xu, X; Goodwin, DG; Ramarao, MK; Nickerson-Nutter, C; Donahue, F; Ku, MS; Clark, JD; McKew, JC Discovery of Ecopladib, an indole inhibitor of cytosolic phospholipase A2alpha. J Med Chem 50:1380-400 (2007) [PubMed]  Article 
Target
Name:
Cytosolic phospholipase A2
Synonyms:
CPLA2 | Lysophospholipase | PA24A_HUMAN | PLA2G4 | PLA2G4A | Phosphatidylcholine 2-acylhydrolase | Phospholipase A2 | Phospholipase A2 group IVA
Type:
Protein
Mol. Mass.:
85219.30
Organism:
Homo sapiens (Human)
Description:
P47712
Residue:
749
Sequence:
MSFIDPYQHIIVEHQYSHKFTVVVLRATKVTKGAFGDMLDTPDPYVELFISTTPDSRKRTRHFNNDINPVWNETFEFILDPNQENVLEITLMDANYVMDETLGTATFTVSSMKVGEKKEVPFIFNQVTEMVLEMSLEVCSCPDLRFSMALCDQEKTFRQQRKEHIRESMKKLLGPKNSEGLHSARDVPVVAILGSGGGFRAMVGFSGVMKALYESGILDCATYVAGLSGSTWYMSTLYSHPDFPEKGPEEINEELMKNVSHNPLLLLTPQKVKRYVESLWKKKSSGQPVTFTDIFGMLIGETLIHNRMNTTLSSLKEKVNTAQCPLPLFTCLHVKPDVSELMFADWVEFSPYEIGMAKYGTFMAPDLFGSKFFMGTVVKKYEENPLHFLMGVWGSAFSILFNRVLGVSGSQSRGSTMEEELENITTKHIVSNDSSDSDDESHEPKGTENEDAGSDYQSDNQASWIHRMIMALVSDSALFNTREGRAGKVHNFMLGLNLNTSYPLSPLSDFATQDSFDDDELDAAVADPDEFERIYEPLDVKSKKIHVVDSGLTFNLPYPLILRPQRGVDLIISFDFSARPSDSSPPFKELLLAEKWAKMNKLPFPKIDPYVFDREGLKECYVFKPKNPDMEKDCPTIIHFVLANINFRKYRAPGVPRETEEEKEIADFDIFDDPESPFSTFNFQYPNQAFKRLHDLMHFNTLNNIDVIKEAMVESIEYRRQNPSRCSVSLSNVEARRFFNKEFLSKPKA
  
Inhibitor
Name:
BDBM50149408
Synonyms:
4-(2-Oxo-hexadecanoylamino)-butyric acid | 4-(2-oxohexadecanamido)butanoic acid | CHEMBL95190
Type:
Small organic molecule
Emp. Form.:
C20H37NO4
Mol. Mass.:
355.5121
SMILES:
CCCCCCCCCCCCCCC(=O)C(=O)NCCCC(O)=O
Structure:
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