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Target
Tyrosine-protein phosphatase non-receptor type 1
Ligand
BDBM50207000
Substrate
n/a
Meas. Tech.
ChEMBL_454791 (CHEMBL886819)
IC50
29000±n/a nM
Citation
 Wan, ZK; Follows, B; Kirincich, S; Wilson, D; Binnun, E; Xu, W; Joseph-McCarthy, D; Wu, J; Smith, M; Zhang, YL; Tam, M; Erbe, D; Tam, S; Saiah, E; Lee, J Probing acid replacements of thiophene PTP1B inhibitors. Bioorg Med Chem Lett 17:2913-20 (2007) [PubMed]  Article 
Target
Name:
Tyrosine-protein phosphatase non-receptor type 1
Synonyms:
PTN1_HUMAN | PTP1B | PTPN1 | Protein tyrosine phosphatase 1B (PTP1B) | Protein tyrosine phosphatase-1B (PTP1B) | Protein-tyrosine phosphatase 1B | Protein-tyrosine phosphatase 1B (PTP1B) | Tyrosine-protein phosphatase non-receptor type 1 | Tyrosine-protein phosphatase non-receptor type 1 (PTP1B)
Type:
Protein phosphatase
Mol. Mass.:
49963.76
Organism:
Homo sapiens (Human)
Description:
Human recombinant GST-fusion PTP1B (1-435).
Residue:
435
Sequence:
MEMEKEFEQIDKSGSWAAIYQDIRHEASDFPCRVAKLPKNKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQYWPQKEEKEMIFEDTNLKLTLISEDIKSYYTVRQLELENLTTQETREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLEMRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRILEPHNGKCREFFPNHQWVKEETQEDKDCPIKEEKGSPLNAAPYGIESMSQDTEVRSRVVGGSLRGAQAASPAKGEPSLPEKDEDHALSYWKPFLVNMCVATVLTAGAYLCYRFLFNSNT
  
Inhibitor
Name:
BDBM50207000
Synonyms:
5-(4-bromo-5-phenylthien-3-yl)-1,2,5-thiadiazolidin-3-one 1,1-dioxide | CHEMBL241250
Type:
Small organic molecule
Emp. Form.:
C12H9BrN2O3S2
Mol. Mass.:
373.245
SMILES:
OC1=CN(c2csc(c2Br)-c2ccccc2)S(=O)(=O)N1 |t:1|
Structure:
Search PDB for entries with ligand similarity: