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Target
Glycine receptor subunit alpha-2
Ligand
BDBM50208060
Substrate
n/a
Meas. Tech.
ChEMBL_429275 (CHEMBL915382)
IC50
7800±n/a nM
Citation
 Jensen, AA; Begum, N; Vogensen, SB; Knapp, KM; Gundertofte, K; Dzyuba, SV; Ishii, H; Nakanishi, K; Kristiansen, U; Strømgaard, K Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem 50:1610-7 (2007) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-2
Synonyms:
GLRA2 | GLRA2_HUMAN
Type:
PROTEIN
Mol. Mass.:
52016.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_429275
Residue:
452
Sequence:
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
  
Inhibitor
Name:
BDBM50208060
Synonyms:
10-methoxy-ginkgolide C | CHEMBL221823
Type:
Small organic molecule
Emp. Form.:
C21H26O11
Mol. Mass.:
454.4245
SMILES:
CO[C@H]1C(=O)O[C@H]2O[C@@]34OC(=O)[C@@H]5[C@H](O)[C@@H](C(C)(C)C)[C@]12[C@]35[C@@H](O)[C@@H]1OC(=O)[C@@H](C)[C@]41O
Structure:
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