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Target
Glycine receptor subunit alpha-2
Ligand
BDBM50208080
Substrate
n/a
Meas. Tech.
ChEMBL_429275 (CHEMBL915382)
IC50
>100000±n/a nM
Citation
 Jensen, AA; Begum, N; Vogensen, SB; Knapp, KM; Gundertofte, K; Dzyuba, SV; Ishii, H; Nakanishi, K; Kristiansen, U; Strømgaard, K Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem 50:1610-7 (2007) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-2
Synonyms:
GLRA2 | GLRA2_HUMAN
Type:
PROTEIN
Mol. Mass.:
52016.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_429275
Residue:
452
Sequence:
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
  
Inhibitor
Name:
BDBM50208080
Synonyms:
1,2;3,14-dianhydro-ginkgolide C | CHEMBL412540
Type:
Small organic molecule
Emp. Form.:
C20H20O9
Mol. Mass.:
404.3674
SMILES:
CC1=C2C(OC1=O)=C[C@]13C4OC(=O)[C@@]21OC1OC(=O)[C@H](O)C31[C@@H]([C@H]4O)C(C)(C)C |c:7,t:1|
Structure:
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