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Target
Glycine receptor subunit alpha-2
Ligand
BDBM50208082
Substrate
n/a
Meas. Tech.
ChEMBL_429275 (CHEMBL915382)
IC50
29000±n/a nM
Citation
 Jensen, AA; Begum, N; Vogensen, SB; Knapp, KM; Gundertofte, K; Dzyuba, SV; Ishii, H; Nakanishi, K; Kristiansen, U; Strømgaard, K Probing the pharmacophore of ginkgolides as glycine receptor antagonists. J Med Chem 50:1610-7 (2007) [PubMed]  Article 
Target
Name:
Glycine receptor subunit alpha-2
Synonyms:
GLRA2 | GLRA2_HUMAN
Type:
PROTEIN
Mol. Mass.:
52016.09
Organism:
Homo sapiens (Human)
Description:
ChEMBL_429275
Residue:
452
Sequence:
MNRQLVNILTALFAFFLETNHFRTAFCKDHDSRSGKQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVNIFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRISKNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEWLSDGPVQVAEGLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAVNFVSRQHKEFLRLRRRQKRQNKEEDVTRESRFNFSGYGMGHCLQVKDGTAVKATPANPLPQPPKDGDAIKKKFVDRAKRIDTISRAAFPLAFLIFNIFYWITYKIIRHEDVHKK
  
Inhibitor
Name:
BDBM50208082
Synonyms:
(1R,3R,6R,7S,8S,9S,10S,11R,12R,13S,16S,17R)-9-azido-8-tert-butyl-6,12,17-trihydroxy-16-methyl-2,4,14,18-tetraoxahexacyclo[8.7.2.0^{1,11}.0^{3,7}.0^{7,11}.0^{13,17}]nonadecane-5,15,19-trione | CHEMBL376289
Type:
Small organic molecule
Emp. Form.:
C20H23N3O10
Mol. Mass.:
465.4107
SMILES:
C[C@@H]1C(=O)O[C@H]2[C@H](O)[C@@]34[C@H]5[C@@H](N=[N+]=[N-])[C@@H](C(C)(C)C)[C@]33[C@@H](OC(=O)[C@@H]3O)O[C@]4(OC5=O)[C@@]12O
Structure:
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