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Target
Bcl2-associated agonist of cell death
Ligand
BDBM50208819
Substrate
n/a
Meas. Tech.
ChEMBL_429497 (CHEMBL918620)
Ki
638±n/a nM
Citation
 Tang, G; Yang, CY; Nikolovska-Coleska, Z; Guo, J; Qiu, S; Wang, R; Gao, W; Wang, G; Stuckey, J; Krajewski, K; Jiang, S; Roller, PP; Wang, S Pyrogallol-based molecules as potent inhibitors of the antiapoptotic Bcl-2 proteins. J Med Chem 50:1723-6 (2007) [PubMed]  Article 
Target
Name:
Bcl2-associated agonist of cell death
Synonyms:
BAD | BAD_HUMAN | BBC6 | BCL2L8 | Bcl-2-binding component 6 | Bcl-2-like protein 8 | Bcl-XL/Bcl-2-associated death promoter | Bcl2 antagonist of cell death | Bcl2-L-8 | Bcl2-antagonist of cell death (BAD)
Type:
PROTEIN
Mol. Mass.:
18393.69
Organism:
Homo sapiens (Human)
Description:
ChEMBL_478760
Residue:
168
Sequence:
MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ
  
Inhibitor
Name:
BDBM50208819
Synonyms:
2-{2,3,4-trihydroxy-5-[methyl-(3-phenylpropyl)sulfamoyl]benzoyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonic acid phenethylamide | CHEMBL376055
Type:
Small organic molecule
Emp. Form.:
C34H37N3O8S2
Mol. Mass.:
679.803
SMILES:
CN(CCCc1ccccc1)S(=O)(=O)c1cc(C(=O)N2CCc3ccc(cc3C2)S(=O)(=O)NCCc2ccccc2)c(O)c(O)c1O
Structure:
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