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Target
Mitogen-activated protein kinase 10
Ligand
BDBM50169995
Substrate
n/a
Meas. Tech.
ChEMBL_459041 (CHEMBL925133)
IC50
3.1±n/a nM
Citation
 Ijjaali, I; Petitet, F; Dubus, E; Barberan, O; Michel, A Assessing potency of c-Jun N-terminal kinase 3 (JNK3) inhibitors using 2D molecular descriptors and binary QSAR methodology. Bioorg Med Chem 15:4256-64 (2007) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 10
Synonyms:
JNK3 | JNK3A | MAP kinase p49 3F12 | MAPK10 | MK10_HUMAN | Mitogen-Activated Protein Kinase 10 (JNK3) | Mitogen-activated protein kinase 10 (Stress-activated protein kinase JNK3) (c-Jun N-terminal kinase 3) (MAP kinase p49 3F12) | Mitogen-activated protein kinase 10/Receptor-interacting serine/threonine-protein kinase 1 | PRKM10 | SAPK1B | Stress-activated protein kinase JNK3 | c-Jun N-terminal kinase 3 (JNK3)
Type:
Enzyme
Mol. Mass.:
52586.89
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
464
Sequence:
MSLHFLYYCSEPTLDVKIAFCQGFDKQVDVSYIAKHYNMSKSKVDNQFYSVEVGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAVLDRNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIISLLNVFTPQKTLEEFQDVYLVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDIWSVGCIMGEMVRHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRNYVENRPKYAGLTFPKLFPDSLFPADSEHNKLKASQARDLLSKMLVIDPAKRISVDDALQHPYINVWYDPAEVEAPPPQIYDKQLDEREHTIEEWKELIYKEVMNSEEKTKNGVVKGQPSPSGAAVNSSESLPPSSSVNDISSMSTDQTLASDTDSSLEASAGPLGCCR
  
Inhibitor
Name:
BDBM50169995
Synonyms:
2-(2-(4-methoxyphenethylamino)pyrimidin-4-yl)-2-(benzo[d]thiazol-2(3H)-ylidene)acetonitrile | CHEMBL370516 | [3H-Benzothiazol-(2Z)-ylidene]-{2-[2-(4-methoxy-phenyl)-ethylamino]-pyrimidin-4-yl}-acetonitrile
Type:
Small organic molecule
Emp. Form.:
C22H19N5OS
Mol. Mass.:
401.484
SMILES:
COc1ccc(CCNc2nccc(n2)C(C#N)c2nc3ccccc3s2)cc1
Structure:
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