Reaction Details Report a problem with these data
Target
Melanocyte-stimulating hormone receptor
Ligand
BDBM50211368
Substrate
n/a
Meas. Tech.
ChEMBL_434963 (CHEMBL919364)
IC50
74.0±n/a nM
Citation
 Bednarek, MA; MacNeil, T; Tang, R; Fong, TM; Cabello, MA; Maroto, M; Teran, A Potent and selective agonists of human melanocortin receptor 5: cyclic analogues of alpha-melanocyte-stimulating hormone. J Med Chem 50:2520-6 (2007) [PubMed]  Article 
Target
Name:
Melanocyte-stimulating hormone receptor
Synonyms:
MC1-R | MC1R | MSH-R | MSHR | MSHR_HUMAN | Melanocortin MC1 | Melanocortin receptor (M1 and M4) | Melanocortin receptor 1 (MC-1) | Melanocortin receptor 1 (MC1-R) | Melanocortin receptor 1 (MC1R)
Type:
Enzyme
Mol. Mass.:
34717.23
Organism:
Homo sapiens (Human)
Description:
Q01726
Residue:
317
Sequence:
MAVQGSQRRLLGSLNSTPTAIPQLGLAANQTGARCLEVSISDGLFLSLGLVSLVENALVVATIAKNRNLHSPMYCFICCLALSDLLVSGSNVLETAVILLLEAGALVARAAVLQQLDNVIDVITCSSMLSSLCFLGAIAVDRYISIFYALRYHSIVTLPRARRAVAAIWVASVVFSTLFIAYYDHVAVLLCLVVFFLAMLVLMAVLYVHMLARACQHAQGIARLHKRQRPVHQGFGLKGAVTLTILLGIFFLCWGPFFLHLTLIVLCPEHPTCGCIFKNFNLFLALIICNAIIDPLIYAFHSQELRRTLKEVLTCSW
  
Inhibitor
Name:
BDBM50211368
Synonyms:
Ac-Nle4-cyclo(Asp5-His6-D-4-Dip-Pro8-Trp9-Lys10)-NH2 | CHEMBL2371964
Type:
Small organic molecule
Emp. Form.:
C55H68N12O9
Mol. Mass.:
1041.2034
SMILES:
[H][C@@]12CCCN1C(=O)[C@H](NC(=O)[C@H](Cc1cnc[nH]1)NC(=O)[C@H](CC(=O)NCCCC[C@H](NC(=O)[C@H](Cc1cc3ccccc3[nH]1)NC2=O)C(N)=O)NC(=O)[C@H](CCCC)NC(C)=O)C(c1ccccc1)c1ccccc1
Structure:
Search PDB for entries with ligand similarity: