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Target
Glutamate receptor 2
Ligand
BDBM50211399
Substrate
n/a
Meas. Tech.
ChEMBL_435003 (CHEMBL920804)
Ki
0.75±n/a nM
Citation
 Vogensen, SB; Frydenvang, K; Greenwood, JR; Postorino, G; Nielsen, B; Pickering, DS; Ebert, B; Bølcho, U; Egebjerg, J; Gajhede, M; Kastrup, JS; Johansen, TN; Clausen, RP; Krogsgaard-Larsen, P A tetrazolyl-substituted subtype-selective AMPA receptor agonist. J Med Chem 50:2408-14 (2007) [PubMed]  Article 
Target
Name:
Glutamate receptor 2
Synonyms:
GRIA2_RAT | Glur2 | Glutamate receptor AMPA 2/4 | Glutamate receptor ionotropic, AMPA 2 | Gria2
Type:
PROTEIN
Mol. Mass.:
98691.74
Organism:
Rattus norvegicus
Description:
ChEMBL_936441
Residue:
883
Sequence:
MQKIMHISVLLSPVLWGLIFGVSSNSIQIGGLFPRGADQEYSAFRVGMVQFSTSEFRLTPHIDNLEVANSFAVTNAFCSQFSRGVYAIFGFYDKKSVNTITSFCGTLHVSFITPSFPTDGTHPFVIQMRPDLKGALLSLIEYYQWDKFAYLYDSDRGLSTLQAVLDSAAEKKWQVTAINVGNINNDKKDETYRSLFQDLELKKERRVILDCERDKVNDIVDQVITIGKHVKGYHYIIANLGFTDGDLLKIQFGGANVSGFQIVDYDDSLVSKFIERWSTLEEKEYPGAHTATIKYTSALTYDAVQVMTEAFRNLRKQRIEISRRGNAGDCLANPAVPWGQGVEIERALKQVQVEGLSGNIKFDQNGKRINYTINIMELKTNGPRKIGYWSEVDKMVVTLTELPSGNDTSGLENKTVVVTTILESPYVMMKKNHEMLEGNERYEGYCVDLAAEIAKHCGFKYKLTIVGDGKYGARDADTKIWNGMVGELVYGKADIAIAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHTEEFEDGRETQSSESTNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLSKQTEIAYGTLDSGSTKEFFRRSKIAVFDKMWTYMRSAEPSVFVRTTAEGVARVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSSLGNAVNLAVLKLNEQGLLDKLKNKWWYDKGECGSGGGDSKEKTSALSLSNVAGVFYILVGGLGLAMLVALIEFCYKSRAEAKRMKVAKNPQNINPSSSQNSQNFATYKEGYNVYGIESVKI
  
Inhibitor
Name:
BDBM50211399
Synonyms:
(RS)-2-amino-3-[3-hydroxy-5-(2-benzyl-2H-5-tetrazolyl)-4-isoxazolyl]propionic acid | 2-AMINO-3-[3-HYDROXY-5-(2-BENZYL-2H-5-TETRAZOLYL)-4-ISOXAZOLYL]-PROPIONIC ACID | CHEMBL388746
Type:
Small organic molecule
Emp. Form.:
C14H14N6O4
Mol. Mass.:
330.2988
SMILES:
NC(Cc1c(o[nH]c1=O)-c1nnn(Cc2ccccc2)n1)C(O)=O
Structure:
Search PDB for entries with ligand similarity: