Reaction Details Report a problem with these data
Target
Peroxisome proliferator-activated receptor delta
Ligand
BDBM50213331
Substrate
n/a
Meas. Tech.
ChEMBL_447443 (CHEMBL896466)
IC50
2.8±n/a nM
Citation
 Filzen, GF; Bratton, L; Cheng, XM; Erasga, N; Geyer, A; Lee, C; Lu, G; Pulaski, J; Sorenson, RJ; Unangst, PC; Trivedi, BK; Xu, X Synthesis and SAR of selective benzothiophene, benzofuran, and indole-based peroxisome proliferator-activated receptor delta agonists. Bioorg Med Chem Lett 17:3630-5 (2007) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor delta
Synonyms:
NR1C2 | NUC1 | NUCI | Nuclear hormone receptor 1 | Nuclear receptor subfamily 1 group C member 2 | PPAR delta | PPAR-beta | PPARB | PPARD | PPARD_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor beta | Peroxisome proliferator-activated receptor delta
Type:
Enzyme
Mol. Mass.:
49910.45
Organism:
Homo sapiens (Human)
Description:
Q03181
Residue:
441
Sequence:
MEQPQEEAPEVREEEEKEEVAEAEGAPELNGGPQHALPSSSYTDLSRSSSPPSLLDQLQMGCDGASCGSLNMECRVCGDKASGFHYGVHACEGCKGFFRRTIRMKLEYEKCERSCKIQKKNRNKCQYCRFQKCLALGMSHNAIRFGRMPEAEKRKLVAGLTANEGSQYNPQVADLKAFSKHIYNAYLKNFNMTKKKARSILTGKASHTAPFVIHDIETLWQAEKGLVWKQLVNGLPPYKEISVHVFYRCQCTTVETVRELTEFAKSIPSFSSLFLNDQVTLLKYGVHEAIFAMLASIVNKDGLLVANGSGFVTREFLRSLRKPFSDIIEPKFEFAVKFNALELDDSDLALFIAAIILCGDRPGLMNVPRVEAIQDTILRALEFHLQANHPDAQYLFPKLLQKMADLRQLVTEHAQMMQRIKKTETETSLHPLLQEIYKDMY
  
Inhibitor
Name:
BDBM50213331
Synonyms:
2-(5-((4-methyl-2-(trifluoromethyl)thiazol-5-yl)methylthio)-1H-indol-1-yl)acetic acid | CHEMBL231690
Type:
Small organic molecule
Emp. Form.:
C16H13F3N2O2S2
Mol. Mass.:
386.412
SMILES:
Cc1nc(sc1CSc1ccc2n(CC(O)=O)ccc2c1)C(F)(F)F
Structure:
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