Reaction Details Report a problem with these data
Target
Glyoxalase I
Ligand
BDBM50213420
Substrate
n/a
Meas. Tech.
ChEMBL_456126 (CHEMBL888135)
Ki
66880±n/a nM
Citation
 More, SS; Vince, R Design, synthesis, and binding studies of bidentate Zn-chelating peptidic inhibitors of glyoxalase-I. Bioorg Med Chem Lett 17:3793-7 (2007) [PubMed]  Article 
Target
Name:
Glyoxalase I
Synonyms:
GLO1 | LGUL_YEAST | Lactoylglutathione lyase
Type:
PROTEIN
Mol. Mass.:
37210.98
Organism:
Saccharomyces cerevisiae
Description:
ChEMBL_571116
Residue:
326
Sequence:
MSTDSTRYPIQIEKASNDPTLLLNHTCLRVKDPARTVKFYTEHFGMKLLSRKDFEEAKFSLYFLSFPKDDIPKNKNGEPDVFSAHGVLELTHNWGTEKNPDYKINNGNEEPHRGFGHICFSVSDINKTCEELESQGVKFKKRLSEGRQKDIAFALGPDGYWIELITYSREGQEYPKGSVGNKFNHTMIRIKNPTRSLEFYQNVLGMKLLRTSEHESAKFTLYFLGYGVPKTDSVFSCESVLELTHNWGTENDPNFHYHNGNSEPQGYGHICISCDDAGALCKEIEVKYGDKIQWSPKFNQGRMKNIAFLKDPDGYSIEVVPHGLIA
  
Inhibitor
Name:
BDBM50213420
Synonyms:
(S)-5-((S)-7-(4-bromobenzyloxy)-1-(carboxymethylamino)-1,5,7-trioxoheptan-2-ylamino)-2-amino-5-oxopentanoic acid | CHEMBL246554
Type:
Small organic molecule
Emp. Form.:
C21H26BrN3O9
Mol. Mass.:
544.35
SMILES:
N[C@@H](CCC(=O)N[C@@H](CCC(=O)CC(=O)OCc1ccc(Br)cc1)C(=O)NCC(O)=O)C(O)=O
Structure:
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