Reaction Details Report a problem with these data
Target
Transcription factor Jun
Ligand
BDBM50213937
Substrate
n/a
Meas. Tech.
ChEMBL_456206 (CHEMBL888216)
IC50
>1000±n/a nM
Citation
 Gao, W; Bussom, S; Grill, SP; Gullen, EA; Hu, YC; Huang, X; Zhong, S; Kaczmarek, C; Gutierrez, J; Francis, S; Baker, DC; Yu, S; Cheng, YC Structure-activity studies of phenanthroindolizidine alkaloids as potential antitumor agents. Bioorg Med Chem Lett 17:4338-42 (2007) [PubMed]  Article 
Target
Name:
Transcription factor Jun
Synonyms:
AP1 | Activator protein 1 | JUN | JUN_HUMAN | Proto-oncogene c-JUN | Transcription factor AP-1 | Transcription factor AP1 | V-jun avian sarcoma virus 17 oncogene homolog | p39
Type:
n/a
Mol. Mass.:
35683.24
Organism:
Homo sapiens (Human)
Description:
P05412
Residue:
331
Sequence:
MTAKMETTFYDDALNASFLPSESGPYGYSNPKILKQSMTLNLADPVGSLKPHLRAKNSDLLTSPDVGLLKLASPELERLIIQSSNGHITTTPTPTQFLCPKNVTDEQEGFAEGFVRALAELHSQNTLPSVTSAAQPVNGAGMVAPAVASVAGGSGSGGFSASLHSEPPVYANLSNFNPGALSSGGGAPSYGAAGLAFPAQPQQQQQPPHHLPQQMPVQHPRLQALKEEPQTVPEMPGETPPLSPIDMESQERIKAERKRMRNRIAASKCRKRKLERIARLEEKVKTLKAQNSELASTANMLREQVAQLKQKVMNHVNSGCQLMLTQQLQTF
  
Inhibitor
Name:
BDBM50213937
Synonyms:
(12aS,13S)-2,6,7-trimethoxy-9,10,11,12,12a,13-hexahydro-9a-aza-cyclopenta[b]triphenylene-3,13-diol | CHEMBL400888
Type:
Small organic molecule
Emp. Form.:
C23H25NO5
Mol. Mass.:
395.4483
SMILES:
COc1cc2c3[C@H](O)[C@@H]4CCCN4Cc3c3cc(OC)c(OC)cc3c2cc1O
Structure:
Search PDB for entries with ligand similarity: