Reaction Details Report a problem with these data
Target
Gamma-aminobutyric acid receptor subunit beta-3
Ligand
BDBM50214670
Substrate
n/a
Meas. Tech.
ChEMBL_448071 (CHEMBL898326)
Ki
8.1±n/a nM
Citation
 Alam, MS; Huang, J; Ozoe, F; Matsumura, F; Ozoe, Y Synthesis, 3D-QSAR, and docking studies of 1-phenyl-1H-1,2,3-triazoles as selective antagonists for beta3 over alpha1beta2gamma2 GABA receptors. Bioorg Med Chem 15:5090-104 (2007) [PubMed]  Article 
Target
Name:
Gamma-aminobutyric acid receptor subunit beta-3
Synonyms:
GABA A receptor alpha-4/beta-3/gamma-2 | GABA receptor beta-3 subunit | GABA-A receptor | GABRB3 | GBRB3_HUMAN | agonist GABA site
Type:
PROTEIN
Mol. Mass.:
54130.51
Organism:
Homo sapiens (Human)
Description:
ChEMBL_448071
Residue:
473
Sequence:
MWGLAGGRLFGIFSAPVLVAVVCCAQSVNDPGNMSFVKETVDKLLKGYDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAYSGIPLNLTLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVFATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLTMTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEKTAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQSMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNLVYWLYYVN
  
Inhibitor
Name:
BDBM50214670
Synonyms:
1-(2,6-dichloro-4-trifluoromethylphenyl)-5-ethyl-4-n-propyl-1H-1,2,3-triazole | CHEMBL236671
Type:
Small organic molecule
Emp. Form.:
C14H14Cl2F3N3
Mol. Mass.:
352.182
SMILES:
CCCc1nnn(c1CC)-c1c(Cl)cc(cc1Cl)C(F)(F)F |(3.56,-17.92,;2.31,-17.01,;2.48,-15.48,;1.23,-14.57,;1.24,-13.03,;-.23,-12.55,;-1.13,-13.8,;-.23,-15.05,;-.71,-16.51,;.32,-17.66,;-2.67,-13.8,;-3.43,-15.13,;-2.66,-16.46,;-4.97,-15.13,;-5.74,-13.79,;-4.97,-12.46,;-3.43,-12.46,;-2.66,-11.13,;-7.28,-13.79,;-8.84,-13.86,;-7.32,-12.25,;-7.23,-15.33,)|
Structure:
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