Reaction Details
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Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM50215071
Substrate
n/a
Meas. Tech.
ChEMBL_437153 (CHEMBL906550)
IC50
93±n/a nM
Citation
Fletcher, DI; Ganellin, CR; Piergentili, A; Dunn, PM; Jenkinson, DH Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)). Bioorg Med Chem 15:5457-79 (2007) [PubMed] Article More Info.:
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel
Type:
PROTEIN
Mol. Mass.:
81476.29
Organism:
Rattus norvegicus
Description:
ChEMBL_494975
Residue:
732
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQLQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
Inhibitor
Name:
BDBM50215071
Synonyms:
CHEMBL375272 | N-[3-(4-quinolinylamino)-propyl]-N-[5-(4-quinolinylamino)-pentyl]-3,5-di-[3-(4-quinolinylamino)-propoxy]-aniline
Type:
Small organic molecule
Emp. Form.:
C56H59N9O2
Mol. Mass.:
890.1268
SMILES:
C(CCNc1ccnc2ccccc12)CCN(CCCNc1ccnc2ccccc12)c1cc(OCCCNc2ccnc3ccccc23)cc(OCCCNc2ccnc3ccccc23)c1
Structure:
