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Target
Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM50215072
Substrate
n/a
Meas. Tech.
ChEMBL_437153 (CHEMBL906550)
IC50
270±n/a nM
Citation
 Fletcher, DI; Ganellin, CR; Piergentili, A; Dunn, PM; Jenkinson, DH Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)). Bioorg Med Chem 15:5457-79 (2007) [PubMed]  Article 
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel
Type:
PROTEIN
Mol. Mass.:
81476.29
Organism:
Rattus norvegicus
Description:
ChEMBL_494975
Residue:
732
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQLQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
  
Inhibitor
Name:
BDBM50215072
Synonyms:
CHEMBL389273 | N-(4-quinolinyl)-3,4-di-[3-(4-quinolinylamino)-propoxyl]-phenethylamine
Type:
Small organic molecule
Emp. Form.:
C41H40N6O2
Mol. Mass.:
648.7953
SMILES:
C(CNc1ccnc2ccccc12)COc1ccc(CCNc2ccnc3ccccc23)cc1OCCCNc1ccnc2ccccc12
Structure:
Search PDB for entries with ligand similarity: