Reaction Details Report a problem with these data
Target
Small conductance calcium-activated potassium channel protein 3
Ligand
BDBM50215073
Substrate
n/a
Meas. Tech.
ChEMBL_437153 (CHEMBL906550)
IC50
490±n/a nM
Citation
Fletcher, DI; Ganellin, CR; Piergentili, A; Dunn, PM; Jenkinson, DH Synthesis and pharmacological testing of polyaminoquinolines as blockers of the apamin-sensitive Ca2+-activated K+ channel (SK(Ca)). Bioorg Med Chem 15:5457-79 (2007) [PubMed] Article
More Info.:
Target
Name:
Small conductance calcium-activated potassium channel protein 3
Synonyms:
KCNN3_RAT | Kcnn3 | SK3 | Small conductance calcium-activated potassium channel
Type:
PROTEIN
Mol. Mass.:
81476.29
Organism:
Rattus norvegicus
Description:
ChEMBL_494975
Residue:
732
Sequence:
MDTSGHFHDSGVGDLDEDPKCPCPSSGDEQQQQQQPPPPSAPPAVPQQPPGPLLQPQPPQLQQQQQQQQQQQQQQQQQQQAPLHPLPQLAQLQSQLVHPGLLHSSPTAFRAPNSANSTAILHPSSRQGSQLNLNDHLLGHSPSSTATSGPGGGSRHRQASPLVHRRDSNPFTEIAMSSCKYSGGVMKPLSRLSASRRNLIEAEPEGQPLQLFSPSNPPEIIISSREDNHAHQTLLHHPNATHNHQHAGTTAGSTTFPKANKRKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGLYSKDSMFSLALKCLISLSTIILLGLIIAYHTREVQLFVIDNGADDWRIAMTYERILYISLEMLVCAIHPIPGEYKFFWTARLAFSYTPSRAEADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRVCERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPHTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRIKNAAANVLRETWLIYKHTKLLKKIDHAKVRKHQRKFLQAIHQLRGVKMEQRKLSDQANTLVDLSKMQNVMYDLITELNDRSEDLEKQIGSLESKLEHLTASFNSLPLLIADTLRQQQQQLLTAFVEARGISVAVGTSHAPPSDSPIGISSTSFPTPYTSSSSC
Inhibitor
Name:
BDBM50215073
Synonyms:
CHEMBL229340 | N-[3-(4-quinolinyl)-aminopropyl]-N-(8-aminooctyl)-3-N'-[3-(4-qionolinyl)-aminopropyl]-carbamoyl-trans propenamide
Type:
Small organic molecule
Emp. Form.:
C36H47N7O2
Mol. Mass.:
609.8041
SMILES:
NCCCCCCCCN(CCCNc1ccnc2ccccc12)C(=O)\C=C\C(=O)NCCCNc1ccnc2ccccc12