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Target
Androgen receptor
Ligand
BDBM50215713
Substrate
n/a
Meas. Tech.
ChEMBL_447721 (CHEMBL896729)
EC50
11.9±n/a nM
Citation
 Manfredi, MC; Bi, Y; Nirschl, AA; Sutton, JC; Seethala, R; Golla, R; Beehler, BC; Sleph, PG; Grover, GJ; Ostrowski, J; Hamann, LG Synthesis and SAR of tetrahydropyrrolo[1,2-b][1,2,5]thiadiazol-2(3H)-one 1,1-dioxide analogues as highly potent selective androgen receptor modulators. Bioorg Med Chem Lett 17:4487-90 (2007) [PubMed]  Article 
Target
Name:
Androgen receptor
Synonyms:
ANDR_MOUSE | Ar | Nr3c4
Type:
PROTEIN
Mol. Mass.:
98196.62
Organism:
Mus musculus
Description:
ChEMBL_945930
Residue:
899
Sequence:
MEVQLGLGRVYPRPPSKTYRGAFQNLFQSVREAIQNPGPRHPEAANIAPPGACLQQRQETSPRRRRRQQHTEDGSPQAHIRGPTGYLALEEEQQPSQQQAASEGHPESSCLPEPGAATAPGKGLPQQPPAPPDQDDSAAPSTLSLLGPTFPGLSSCSADIKDILNEAGTMQLLQQQQQQQQHQQQHQQHQQQQEVISEGSSARAREATGAPSSSKDSYLGGNSTISDSAKELCKAVSVSMGLGVEALEHLSPGEQLRGDCMYASLLGGPPAVRPTPCAPLPECKGLPLDEGPGKSTEETAEYSSFKGGYAKGLEGESLGCSGSSEAGSSGTLEIPSSLSLYKSGALDEAAAYQNRDYYNFPLALSGPPHPPPPTHPHARIKLENPLDYGSAWAAAAAQCRYGDLGSLHGGSVAGPSTGSPPATTSSSWHTLFTAEEGQLYGPGGGGGSSSPSDAGPVAPYGYTRPPQGLTSQESDYSASEVWYPGGVVNRVPYPSPNCVKSEMGPWMENYSGPYGDMRLDSTRDHVLPIDYYFPPQKTCLICGDEASGCHYGALTCGSCKVFFKRAAEGKQKYLCASRNDCTIDKFRRKNCPSCRLRKCYEAGMTLGARKLKKLGNLKLQEEGENSNAGSPTEDPSQKMTVSHIEGYECQPIFLNVLEAIEPGVVCAGHDNNQPDSFAALLSSLNELGERQLVHVVKWAKALPGFRNLHVDDQMAVIQYSWMGLMVFAMGWRSFTNVNSRMLYFAPDLVFNEYRMHKSRMYSQCVRMRHLSQEFGWLQITPQEFLCMKALLLFSIIPVDGLKNQKFFDELRMNYIKELDRIIACKRKNPTSCSRRFYQLTKLLDSVQPIARELHQFTFDLLIKSHMVSVDFPEMMAEIISVQVPKILSGKVKPIYFHTQ
  
Inhibitor
Name:
BDBM50215713
Synonyms:
2-Chloro-4-((3aS,4R)-4-hydroxy-1,1,3-trioxo-tetrahydro-1lambda*6*-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile | 2-chloro-4-((3aS,4R)-4-hydroxy-1,1,3-trioxo-tetrahydro-1lambda6-thia-2,6a-diaza-pentalen-2-yl)-3-methyl-benzonitrile | CHEMBL233773
Type:
Small organic molecule
Emp. Form.:
C13H12ClN3O4S
Mol. Mass.:
341.77
SMILES:
Cc1c(Cl)c(ccc1N1C(=O)[C@@H]2[C@H](O)CCN2S1(=O)=O)C#N |r|
Structure:
Search PDB for entries with ligand similarity: