Reaction Details
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Peroxisome proliferator-activated receptor gamma
Ligand
BDBM50216936
Substrate
n/a
Meas. Tech.
ChEMBL_456814 (CHEMBL924197)
EC50
31±n/a nM
Citation
Wickens, P; Zhang, C; Ma, X; Zhao, Q; Amatruda, J; Bullock, W; Burns, M; Cantin, LD; Chuang, CY; Claus, T; Dai, M; Dela Cruz, F; Dickson, D; Ehrgott, FJ; Fan, D; Heald, S; Hentemann, M; Iwuagwu, CI; Johnson, JS; Kumarasinghe, E; Ladner, D; Lavoie, R; Liang, S; Livingston, JN; Lowe, D; Magnuson, S; Mannelly, G; Mugge, I; Ogutu, H; Pleasic-Williams, S; Schoenleber, RW; Shapiro, J; Shelekhin, T; Sweet, L; Town, C; Tsutsumi, M Indanylacetic acids as PPAR-delta activator insulin sensitizers. Bioorg Med Chem Lett 17:4369-73 (2007) [PubMed] Article More Info.:
Target
Name:
Peroxisome proliferator-activated receptor gamma
Synonyms:
NR1C3 | Nuclear receptor subfamily 1 group C member 3 | PPAR-gamma | PPARG | PPARG_HUMAN | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor gamma (PPAR gamma) | Peroxisome proliferator-activated receptor gamma (PPARG) | Peroxisome proliferator-activated receptor gamma (PPARĪ³) | Peroxisome proliferator-activated receptor gamma/Nuclear receptor corepressor 2 | peroxisome proliferator-activated receptor gamma isoform 2
Type:
Nuclear Receptor
Mol. Mass.:
57613.46
Organism:
Homo sapiens (Human)
Description:
P37231
Residue:
505
Sequence:
MGETLGDSPIDPESDSFTDTLSANISQEMTMVDTEMPFWPTNFGISSVDLSVMEDHSHSFDIKPFTTVDFSSISTPHYEDIPFTRTDPVVADYKYDLKLQEYQSAIKVEPASPPYYSEKTQLYNKPHEEPSNSLMAIECRVCGDKASGFHYGVHACEGCKGFFRRTIRLKLIYDRCDLNCRIHKKSRNKCQYCRFQKCLAVGMSHNAIRFGRMPQAEKEKLLAEISSDIDQLNPESADLRALAKHLYDSYIKSFPLTKAKARAILTGKTTDKSPFVIYDMNSLMMGEDKIKFKHITPLQEQSKEVAIRIFQGCQFRSVEAVQEITEYAKSIPGFVNLDLNDQVTLLKYGVHEIIYTMLASLMNKDGVLISEGQGFMTREFLKSLRKPFGDFMEPKFEFAVKFNALELDDSDLAIFIAVIILSGDRPGLLNVKPIEDIQDNLLQALELQLKLNHPESSQLFAKLLQKMTDLRQIVTEHVQLLQVIKKTETDMSLHPLLQEIYKDLY
Inhibitor
Name:
BDBM50216936
Synonyms:
(S)-2-(5-(2-(2-(4-ethylphenyl)-1,4-dimethyl-1H-imidazol-5-yl)ethoxy)-2,3-dihydro-1H-inden-1-yl)acetic acid | CHEMBL246801
Type:
Small organic molecule
Emp. Form.:
C26H30N2O3
Mol. Mass.:
418.528
SMILES:
CCc1ccc(cc1)-c1nc(C)c(CCOc2ccc3[C@H](CC(O)=O)CCc3c2)n1C
Structure:
