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Target
Cholesteryl ester transfer protein
Ligand
BDBM50128183
Substrate
n/a
Meas. Tech.
ChEMBL_448557 (CHEMBL897706)
IC50
300±n/a nM
Citation
 Castilho, MS; Guido, RV; Andricopulo, AD 2D Quantitative structure-activity relationship studies on a series of cholesteryl ester transfer protein inhibitors. Bioorg Med Chem 15:6242-52 (2007) [PubMed]  Article 
Target
Name:
Cholesteryl ester transfer protein
Synonyms:
CETP | CETP_HUMAN | Cholesteryl ester transfer protein (CETP) | Lipid transfer protein I
Type:
Enzyme
Mol. Mass.:
54751.53
Organism:
Homo sapiens (Human)
Description:
P11597
Residue:
493
Sequence:
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQTAFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSIDVSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDSGRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQICKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHKGHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRLMLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISCQNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLSLLDFQITPKTVSNLTESSSESVQSFLQSMITAVGIPEVMSRLEVVFTALMNSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
  
Inhibitor
Name:
BDBM50128183
Synonyms:
1,1,1-Trifluoro-3-{(3-isopropoxy-phenyl)-[3-(1,1,2,2-tetrafluoro-ethoxy)-benzyl]-amino}-propan-2-ol | 1,1,1-trifluoro-3-((3-isopropoxyphenyl)(3-(1,1,2,2-tetrafluoroethoxy)benzyl)amino)propan-2-ol | 3-((3-(1,1,2,2-tetrafluoroethoxy)benzyl)(3-isopropoxyphenyl)amino)-1,1,1-trifluoropropan-2-ol | CHEMBL68726
Type:
Small organic molecule
Emp. Form.:
C21H22F7NO3
Mol. Mass.:
469.3931
SMILES:
CC(C)Oc1cccc(c1)N(CC(O)C(F)(F)F)Cc1cccc(OC(F)(F)C(F)F)c1
Structure:
Search PDB for entries with ligand similarity: