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Target
D(3) dopamine receptor
Ligand
BDBM50219938
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
2.8±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219938
Synonyms:
CHEMBL391699 | N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)ethyl)cyclohexyl)pyridine-3-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C25H32F3N3O3S
Mol. Mass.:
511.6
SMILES:
FC(F)(F)c1cccc(OC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3cccnc3)CC2)c1 |wU:19.22,wD:16.15,(22.97,-37.44,;21.64,-38.22,;22.41,-39.55,;20.86,-36.89,;20.31,-38.99,;20.31,-40.54,;18.98,-41.3,;17.64,-40.53,;17.66,-38.99,;16.33,-38.22,;15,-38.98,;14.99,-40.52,;13.66,-41.28,;12.33,-40.51,;11,-41.28,;9.67,-40.51,;8.33,-41.28,;7,-40.51,;5.66,-41.28,;5.66,-42.83,;7,-43.59,;8.33,-42.83,;4.33,-43.62,;2.97,-42.86,;3.55,-41.44,;2.38,-44.28,;1.48,-42.45,;1.09,-40.95,;-.4,-40.55,;-1.5,-41.63,;-1.09,-43.13,;.39,-43.54,;12.32,-38.98,;13.67,-38.21,;18.98,-38.23,)|
Structure:
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