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Target
D(3) dopamine receptor
Ligand
BDBM50219940
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
0.5±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219940
Synonyms:
CHEMBL240271 | N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)benzyl)piperidin-1-yl)ethyl)cyclohexyl)-4-(1H-pyrazol-1-yl)benzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C30H37F3N4O2S
Mol. Mass.:
574.701
SMILES:
FC(F)(F)c1cccc(CC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(cc3)-n3cccn3)CC2)c1 |wU:19.22,wD:16.15,(19.92,-6.09,;18.59,-6.87,;19.37,-8.2,;17.82,-5.54,;17.26,-7.64,;17.26,-9.19,;15.92,-9.95,;14.6,-9.18,;14.61,-7.64,;13.28,-6.86,;11.94,-7.63,;11.94,-9.17,;10.6,-9.94,;9.27,-9.17,;7.94,-9.94,;6.6,-9.17,;5.27,-9.94,;3.93,-9.17,;2.6,-9.94,;2.6,-11.48,;3.93,-12.25,;5.27,-11.48,;1.26,-12.27,;-.09,-11.52,;-.86,-12.85,;.66,-10.17,;-1.44,-10.74,;-1.43,-9.19,;-2.76,-8.42,;-4.11,-9.19,;-4.1,-10.75,;-2.76,-11.51,;-5.44,-8.42,;-5.61,-6.89,;-7.11,-6.58,;-7.88,-7.91,;-6.85,-9.05,;9.27,-7.63,;10.61,-6.86,;15.93,-6.87,)|
Structure:
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