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Target
D(3) dopamine receptor
Ligand
BDBM50219943
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
0.4±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219943
Synonyms:
CHEMBL428910 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)cyclohexyl)pyridine-3-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C25H30F3N5O2S
Mol. Mass.:
521.598
SMILES:
FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccnc2)CC1)C#N |wU:19.23,wD:16.16,(15,3.82,;15.01,2.27,;16.55,2.28,;13.47,2.26,;15.01,.73,;16.35,-.04,;16.34,-1.58,;15.01,-2.35,;13.68,-1.56,;13.68,-.03,;12.35,-2.33,;12.34,-3.87,;11.01,-4.63,;9.68,-3.85,;8.35,-4.62,;7.01,-3.85,;5.68,-4.62,;4.34,-3.84,;3,-4.62,;3,-6.17,;4.34,-6.94,;5.68,-6.17,;1.67,-6.94,;.34,-6.17,;-.44,-7.5,;1.11,-4.84,;-1,-5.39,;-.99,-3.84,;-2.32,-3.06,;-3.67,-3.83,;-3.67,-5.39,;-2.33,-6.16,;9.67,-2.32,;11.01,-1.55,;17.67,-2.36,;19,-3.14,)|
Structure:
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