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Target
D(3) dopamine receptor
Ligand
BDBM50219937
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
3±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219937
Synonyms:
4-chloro-N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)phenylamino)piperidin-1-yl)ethyl)cyclohexyl)benzenesulfonamide | CHEMBL393556
Type:
Small organic molecule
Emp. Form.:
C26H33ClF3N3O2S
Mol. Mass.:
544.072
SMILES:
FC(F)(F)c1cccc(NC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc(Cl)cc3)CC2)c1 |wU:19.22,wD:16.15,(13.27,-8.06,;11.94,-8.84,;12.72,-10.18,;11.17,-7.51,;10.61,-9.61,;10.61,-11.16,;9.27,-11.92,;7.94,-11.15,;7.95,-9.61,;6.63,-8.84,;5.28,-9.6,;5.28,-11.14,;3.95,-11.91,;2.62,-11.14,;1.28,-11.91,;-.05,-11.14,;-1.39,-11.91,;-2.72,-11.14,;-4.06,-11.91,;-4.06,-13.45,;-2.72,-14.22,;-1.39,-13.45,;-5.4,-14.25,;-6.76,-13.49,;-7.52,-14.82,;-6.01,-12.15,;-8.09,-12.71,;-8.1,-11.16,;-9.44,-10.39,;-10.78,-11.16,;-12.11,-10.39,;-10.77,-12.72,;-9.44,-13.48,;2.62,-9.6,;3.95,-8.84,;9.28,-8.84,)|
Structure:
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