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Target
D(2) dopamine receptor
Ligand
BDBM50219949
Substrate
n/a
Meas. Tech.
ChEMBL_449064 (CHEMBL898269)
IC50
5.3±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50219949
Synonyms:
3-oxo-N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)phenoxy)piperidin-1-yl)ethyl)cyclohexyl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-6-sulfonamide | CHEMBL240480
Type:
Small organic molecule
Emp. Form.:
C28H34F3N3O5S
Mol. Mass.:
581.647
SMILES:
FC(F)(F)c1cccc(OC2CCN(CC[C@H]3CC[C@@H](CC3)NS(=O)(=O)c3ccc4OCC(=O)Nc4c3)CC2)c1 |wU:19.22,wD:16.15,(24.03,-4.86,;22.7,-5.65,;23.47,-6.98,;21.92,-4.33,;21.37,-6.41,;21.37,-7.96,;20.03,-8.72,;18.71,-7.95,;18.72,-6.41,;17.39,-5.64,;16.06,-6.4,;16.05,-7.94,;14.72,-8.71,;13.39,-7.94,;12.07,-8.71,;10.72,-7.94,;9.4,-8.71,;8.07,-7.94,;6.73,-8.71,;6.73,-10.24,;8.07,-11.01,;9.4,-10.24,;5.4,-11.04,;4.04,-10.29,;3.28,-11.62,;4.79,-8.95,;2.7,-9.51,;1.38,-10.28,;.04,-9.52,;.03,-7.97,;-1.31,-7.2,;-1.31,-5.65,;.04,-4.87,;.04,-3.33,;1.38,-5.65,;1.38,-7.2,;2.7,-7.97,;13.39,-6.4,;14.73,-5.64,;20.03,-5.65,)|
Structure:
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