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Target
D(2) dopamine receptor
Ligand
BDBM50219944
Substrate
n/a
Meas. Tech.
ChEMBL_449064 (CHEMBL898269)
IC50
28±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
  
Inhibitor
Name:
BDBM50219944
Synonyms:
CHEMBL239847 | N-((1r,4r)-4-(2-(4-(4-bromo-2-methoxyphenyl)piperazin-1-yl)ethyl)cyclohexyl)-4-methoxybenzenesulfonamide
Type:
Small organic molecule
Emp. Form.:
C26H36BrN3O4S
Mol. Mass.:
566.551
SMILES:
COc1ccc(cc1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2ccc(Br)cc2OC)CC1 |wU:12.12,wD:15.16,(-10.86,-24,;-10.86,-25.54,;-9.52,-26.31,;-8.18,-25.54,;-6.84,-26.31,;-6.85,-27.85,;-8.18,-28.62,;-9.51,-27.86,;-5.5,-28.62,;-6.26,-29.97,;-4.75,-27.28,;-4.15,-29.39,;-2.81,-28.59,;-2.81,-27.05,;-1.47,-26.28,;-.14,-27.05,;1.19,-26.28,;2.53,-27.05,;3.86,-26.28,;5.2,-27.05,;6.52,-26.29,;6.53,-24.75,;5.2,-23.98,;3.85,-24.74,;7.86,-23.98,;7.86,-22.45,;9.19,-21.69,;10.52,-22.46,;11.86,-21.69,;10.52,-24,;9.19,-24.76,;9.18,-26.3,;7.84,-27.06,;-.14,-28.59,;-1.47,-29.36,)|
Structure:
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