Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50219946
Substrate
n/a
Meas. Tech.
ChEMBL_449064 (CHEMBL898269)
IC50
29±n/a nM
Citation
Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed] Article
More Info.:
Target
Name:
D(2) dopamine receptor
Synonyms:
DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2_RAT | Dopamine D2 receptor | Dopamine2-like | Drd2
Type:
G Protein-Coupled Receptor (GPCR)
Mol. Mass.:
50931.60
Organism:
Rattus norvegicus (rat)
Description:
P61169
Residue:
444
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSEGKADRPHYNYYAMLLTLLIFIIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMIAIVWVLSFTISCPLLFGLNNTDQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRKRRKRVNTKRSSRAFRANLKTPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRMDAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSNPDSPAKPEKNGHAKIVNPRIAKFFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFMKILHC
Inhibitor
Name:
BDBM50219946
Synonyms:
CHEMBL391700 | N-((1r,4r)-4-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)cyclohexyl)pyridine-3-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C24H31F3N4O2S
Mol. Mass.:
496.589
SMILES:
FC(F)(F)c1cccc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccnc2)CC1 |wU:19.23,wD:16.16,(14.09,1.13,;12.77,1.89,;12,.57,;13.55,3.23,;11.44,2.67,;11.44,4.21,;10.11,4.98,;8.78,4.22,;8.79,2.69,;10.11,1.91,;7.45,1.92,;7.44,.38,;6.12,-.38,;4.78,.4,;3.45,-.37,;2.12,.39,;.78,-.38,;-.55,.39,;-1.89,-.38,;-1.89,-1.92,;-.55,-2.69,;.78,-1.92,;-3.22,-2.72,;-4.56,-1.97,;-5.32,-3.3,;-3.8,-.63,;-5.91,-1.2,;-7.23,-1.97,;-8.56,-1.2,;-8.57,.35,;-7.23,1.12,;-5.9,.35,;4.78,1.93,;6.12,2.69,)|