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Target
D(3) dopamine receptor
Ligand
BDBM50219936
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
3.3±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219936
Synonyms:
4-bromo-N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)cyclohexyl)benzenesulfonamide | CHEMBL239846
Type:
Small organic molecule
Emp. Form.:
C26H30BrF3N4O2S
Mol. Mass.:
599.506
SMILES:
FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2ccc(Br)cc2)CC1)C#N |wU:19.23,wD:16.16,(40.83,-11.4,;39.5,-10.63,;38.73,-11.96,;40.28,-9.3,;38.17,-9.85,;38.18,-8.31,;36.83,-7.54,;35.51,-8.31,;35.52,-9.84,;36.83,-10.62,;34.18,-10.6,;34.18,-12.14,;32.84,-12.9,;31.51,-12.13,;30.17,-12.9,;28.85,-12.13,;27.52,-12.9,;26.18,-12.13,;24.84,-12.9,;24.84,-14.45,;26.18,-15.22,;27.52,-14.45,;23.5,-15.24,;22.14,-14.48,;21.38,-15.82,;22.9,-13.14,;20.81,-13.7,;20.81,-12.16,;19.48,-11.39,;18.14,-12.16,;16.81,-11.39,;18.14,-13.71,;19.47,-14.47,;31.51,-10.59,;32.85,-9.83,;36.83,-6,;36.83,-4.47,)|
Structure:
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