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Target
D(3) dopamine receptor
Ligand
BDBM50219950
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
5.8±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219950
Synonyms:
3-cyano-N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)cyclohexyl)benzenesulfonamide | CHEMBL392527
Type:
Small organic molecule
Emp. Form.:
C27H30F3N5O2S
Mol. Mass.:
545.62
SMILES:
FC(F)(F)c1cc(cc(c1)N1CCN(CC[C@H]2CC[C@@H](CC2)NS(=O)(=O)c2cccc(c2)C#N)CC1)C#N |wU:19.23,wD:16.16,(20.94,-42.03,;19.62,-41.26,;18.85,-42.59,;20.4,-39.93,;18.29,-40.49,;18.29,-38.95,;16.96,-38.17,;15.63,-38.94,;15.63,-40.47,;16.95,-41.25,;14.29,-41.24,;14.29,-42.78,;12.96,-43.54,;11.62,-42.76,;10.29,-43.53,;8.95,-42.76,;7.63,-43.53,;6.29,-42.77,;4.95,-43.53,;4.95,-45.08,;6.29,-45.85,;7.63,-45.08,;3.61,-45.88,;2.26,-45.11,;1.5,-46.46,;3.01,-43.77,;.91,-44.34,;-.41,-45.11,;-1.74,-44.34,;-1.75,-42.8,;-.41,-42.03,;.92,-42.8,;-.41,-40.49,;-.41,-38.94,;11.62,-41.23,;12.97,-40.46,;16.95,-36.63,;16.95,-35.1,)|
Structure:
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