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Target
D(3) dopamine receptor
Ligand
BDBM50219941
Substrate
n/a
Meas. Tech.
ChEMBL_449063 (CHEMBL898268)
IC50
4.2±n/a nM
Citation
 Agai-Csongor, E; Nógrádi, K; Galambos, J; Vágó, I; Bielik, A; Magdó, I; Ignácz-Szendrei, G; Keseru, GM; Greiner, I; Laszlovszky, I; Schmidt, E; Kiss, B; Sághy, K; Laszy, J; Gyertyán, I; Zájer-Balázs, M; Gémesi, L; Domány, G Novel sulfonamides having dual dopamine D2 and D3 receptor affinity show in vivo antipsychotic efficacy with beneficial cognitive and EPS profile. Bioorg Med Chem Lett 17:5340-4 (2007) [PubMed]  Article 
Target
Name:
D(3) dopamine receptor
Synonyms:
DOPAMINE D3 | DRD3_RAT | Dopamine D3 receptor | Drd3
Type:
Protein
Mol. Mass.:
49540.58
Organism:
Rattus norvegicus (Rat)
Description:
P19020
Residue:
446
Sequence:
MAPLSQISTHLNSTCGAENSTGVNRARPHAYYALSYCALILAIIFGNGLVCAAVLRERALQTTTNYLVVSLAVADLLVATLVMPWVVYLEVTGGVWNFSRICCDVFVTLDVMMCTASILNLCAISIDRYTAVVMPVHYQHGTGQSSCRRVALMITAVWVLAFAVSCPLLFGFNTTGDPSICSISNPDFVIYSSVVSFYVPFGVTVLVYARIYIVLRQRQRKRILTRQNSQCISIRPGFPQQSSCLRLHPIRQFSIRARFLSDATGQMEHIEDKQYPQKCQDPLLSHLQPPSPGQTHGGLKRYYSICQDTALRHPSLEGGAGMSPVERTRNSLSPTMAPKLSLEVRKLSNGRLSTSLRLGPLQPRGVPLREKKATQMVVIVLGAFIVCWLPFFLTHVLNTHCQACHVSPELYRATTWLGYVNSALNPVIYTTFNVEFRKAFLKILSC
  
Inhibitor
Name:
BDBM50219941
Synonyms:
CHEMBL240909 | N-((1r,4r)-4-(2-(4-(3-cyano-5-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)cyclohexyl)-6-methylpyridine-3-sulfonamide
Type:
Small organic molecule
Emp. Form.:
C26H32F3N5O2S
Mol. Mass.:
535.625
SMILES:
Cc1ccc(cn1)S(=O)(=O)N[C@H]1CC[C@H](CCN2CCN(CC2)c2cc(cc(c2)C(F)(F)F)C#N)CC1 |wU:11.11,wD:14.15,(-4.97,-20.83,;-3.63,-21.59,;-3.63,-23.15,;-2.29,-23.91,;-.96,-23.14,;-.95,-21.59,;-2.29,-20.83,;.38,-23.91,;-.38,-25.26,;1.14,-22.58,;1.72,-24.68,;3.06,-23.88,;3.06,-22.33,;4.4,-21.56,;5.73,-22.33,;7.07,-21.56,;8.4,-22.33,;9.74,-21.56,;11.07,-22.33,;12.39,-21.57,;12.4,-20.03,;11.07,-19.26,;9.73,-20.02,;13.74,-19.26,;13.74,-17.73,;15.06,-16.96,;16.41,-17.74,;16.4,-19.28,;15.06,-20.04,;17.73,-20.06,;19.06,-20.82,;16.96,-21.38,;18.51,-18.72,;15.06,-15.42,;15.05,-13.89,;5.73,-23.88,;4.4,-24.65,)|
Structure:
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