Reaction Details Report a problem with these data
Target
Hydroxycarboxylic acid receptor 3
Ligand
BDBM50220833
Substrate
n/a
Meas. Tech.
ChEMBL_449369 (CHEMBL899636)
EC50
724±n/a nM
Citation
 Skinner, PJ; Cherrier, MC; Webb, PJ; Shin, YJ; Gharbaoui, T; Lindstrom, A; Hong, V; Tamura, SY; Dang, HT; Pride, CC; Chen, R; Richman, JG; Connolly, DT; Semple, G Fluorinated pyrazole acids are agonists of the high affinity niacin receptor GPR109a. Bioorg Med Chem Lett 17:5620-3 (2007) [PubMed]  Article 
Target
Name:
Hydroxycarboxylic acid receptor 3
Synonyms:
G-protein coupled receptor 109B | G-protein coupled receptor HM74 | G-protein coupled receptor HM74B | GPR109B | HCA3 | HCAR3 | HCAR3_HUMAN | HM74 nicotinic acid GPCR | HM74B | Hydroxycarboxylic acid receptor 3 | NIACR2 | Niacin receptor 2 | Nicotinic acid receptor 2
Type:
Enzyme Catalytic Domain
Mol. Mass.:
44498.06
Organism:
Homo sapiens (Human)
Description:
GPR109B 0 HUMAN::P49019
Residue:
387
Sequence:
MNRHHLQDHFLEIDKKNCCVFRDDFIAKVLPPVLGLEFIFGLLGNGLALWIFCFHLKSWKSSRIFLFNLAVADFLLIICLPFVMDYYVRRSDWKFGDIPCRLVLFMFAMNRQGSIIFLTVVAVDRYFRVVHPHHALNKISNWTAAIISCLLWGITVGLTVHLLKKKLLIQNGTANVCISFSICHTFRWHEAMFLLEFFLPLGIILFCSARIIWSLRQRQMDRHAKIKRAITFIMVVAIVFVICFLPSVVVRIHIFWLLHTSGTQNCEVYRSVDLAFFITLSFTYMNSMLDPVVYYFSSPSFPNFFSTLINRCLQRKITGEPDNNRSTSVELTGDPNKTRGAPEALIANSGEPWSPSYLGPTSNNHSKKGHCHQEPASLEKQLGCCIE
  
Inhibitor
Name:
BDBM50220833
Synonyms:
5-(5-propyl-1H-pyrazol-3-yl)-1H-tetrazole | CHEMBL393064
Type:
Small organic molecule
Emp. Form.:
C7H10N6
Mol. Mass.:
178.1945
SMILES:
CCCc1cc(n[nH]1)-c1nnn[nH]1
Structure:
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