Reaction Details Report a problem with these data
Target
D(2) dopamine receptor
Ligand
BDBM50221663
Substrate
n/a
Meas. Tech.
ChEMBL_449681 (CHEMBL898785)
Ki
1400±n/a nM
Citation
 Rodriguez Loaiza, P; Löber, S; Hübner, H; Gmeiner, P Click chemistry based solid phase supported synthesis of dopaminergic phenylacetylenes. Bioorg Med Chem 15:7248-57 (2007) [PubMed]  Article 
Target
Name:
D(2) dopamine receptor
Synonyms:
D(2) dopamine receptor | DOPAMINE D2 | DOPAMINE D2 Long | DOPAMINE D2 Short | DRD2 | DRD2_HUMAN | Dopamine D2 receptor | Dopamine D2 receptor (D2) | Dopamine D2 receptor (D2R) | Dopamine D2A | Dopamine2-like | d2
Type:
Cell-surface receptors
Mol. Mass.:
50647.10
Organism:
Homo sapiens (Human)
Description:
P14416
Residue:
443
Sequence:
MDPLNLSWYDDDLERQNWSRPFNGSDGKADRPHYNYYATLLTLLIAVIVFGNVLVCMAVSREKALQTTTNYLIVSLAVADLLVATLVMPWVVYLEVVGEWKFSRIHCDIFVTLDVMMCTASILNLCAISIDRYTAVAMPMLYNTRYSSKRRVTVMISIVWVLSFTISCPLLFGLNNADQNECIIANPAFVVYSSIVSFYVPFIVTLLVYIKIYIVLRRRRKRVNTKRSSRAFRAHLRAPLKGNCTHPEDMKLCTVIMKSNGSFPVNRRRVEAARRAQELEMEMLSSTSPPERTRYSPIPPSHHQLTLPDPSHHGLHSTPDSPAKPEKNGHAKDHPKIAKIFEIQTMPNGKTRTSLKTMSRRKLSQQKEKKATQMLAIVLGVFIICWLPFFITHILNIHCDCNIPPVLYSAFTWLGYVNSAVNPIIYTTFNIEFRKAFLKILHC
  
Inhibitor
Name:
BDBM50221663
Synonyms:
CHEMBL241424 | N-{4-[4-(2-methoxyphenyl)piperazin-1-yl]butyl}-4-phenylethynylbenzamide
Type:
Small organic molecule
Emp. Form.:
C30H33N3O2
Mol. Mass.:
467.6019
SMILES:
COc1ccccc1N1CCN(CCCCNC(=O)c2ccc(cc2)C#Cc2ccccc2)CC1
Structure:
Search PDB for entries with ligand similarity: