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Target
Coagulation factor X
Ligand
BDBM50222063
Substrate
n/a
Meas. Tech.
ChEMBL_457737 (CHEMBL924015)
IC50
5.5±n/a nM
Citation
 Shi, Y; Sitkoff, D; Zhang, J; Han, W; Hu, Z; Stein, PD; Wang, Y; Kennedy, LJ; O'Connor, SP; Ahmad, S; Liu, EC; Seiler, SM; Lam, PY; Robl, JA; Macor, JE; Atwal, KS; Zahler, R Amino(methyl) pyrrolidines as novel scaffolds for factor Xa inhibitors. Bioorg Med Chem Lett 17:5952-8 (2007) [PubMed]  Article 
Target
Name:
Coagulation factor X
Synonyms:
Activated coagulation factor X (FXa) | Activated factor Xa heavy chain | Coagulation factor X precursor | Coagulation factor Xa | F10 | FA10_HUMAN | Factor X heavy chain | Factor X light chain | Factor Xa | Stuart factor | Stuart-Prower factor
Type:
Enzyme
Mol. Mass.:
54726.60
Organism:
Homo sapiens (Human)
Description:
n/a
Residue:
488
Sequence:
MGRPLHLVLLSASLAGLLLLGESLFIRREQANNILARVTRANSFLEEMKKGHLERECMEETCSYEEAREVFEDSDKTNEFWNKYKDGDQCETSPCQNQGKCKDGLGEYTCTCLEGFEGKNCELFTRKLCSLDNGDCDQFCHEEQNSVVCSCARGYTLADNGKACIPTGPYPCGKQTLERRKRSVAQATSSSGEAPDSITWKPYDAADLDPTENPFDLLDFNQTQPERGDNNLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQAKRFKVRVGDRNTEQEEGGEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPACLPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRNSCKLSSSFIITQNMFCAGYDTKQEDACQGDSGGPHVTRFKDTYFVTGIVSWGEGCARKGKYGIYTKVTAFLKWIDRSMKTRGLPKAKSHAPEVITSSPLK
  
Inhibitor
Name:
BDBM50222063
Synonyms:
(R,E)-2-(5-chlorothiophen-2-yl)-N-((1-(1-(pyridin-4-yl)piperidine-4-carbonyl)pyrrolidin-3-yl)methyl)ethenesulfonamide | CHEMBL248661
Type:
Small organic molecule
Emp. Form.:
C22H27ClN4O3S2
Mol. Mass.:
495.058
SMILES:
Clc1ccc(\C=C\S(=O)(=O)NC[C@@H]2CCN(C2)C(=O)C2CCN(CC2)c2ccncc2)s1
Structure:
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