Reaction Details Report a problem with these data
Target
Cannabinoid receptor 1
Ligand
BDBM50292327
Substrate
n/a
Meas. Tech.
ChEMBL_457977 (CHEMBL924246)
EC50
8440±n/a nM
Citation
 Cano, C; Goya, P; Paez, JA; Girón, R; Sánchez, E; Martín, MI Discovery of 1,1-dioxo-1,2,6-thiadiazine-5-carboxamide derivatives as cannabinoid-like molecules with agonist and antagonist activity. Bioorg Med Chem 15:7480-93 (2007) [PubMed]  Article 
Target
Name:
Cannabinoid receptor 1
Synonyms:
Brain-type cannabinoid receptor | CANNABINOID CB1 | CB-R | CB1 | CNR1_MOUSE | Cannabinoid CB1 receptor | Cannabinoid receptor | Cnr1
Type:
Enzyme
Mol. Mass.:
52842.52
Organism:
Mus musculus (Mouse)
Description:
P47746
Residue:
473
Sequence:
MKSILDGLADTTFRTITTDLLYVGSNDIQYEDIKGDMASKLGYFPQKFPLTSFRGSPFQEKMTAGDNSPLVPAGDTTNITEFYNKSLSSFKENEDNIQCGENFMDMECFMILNPSQQLAIAVLSLTLGTFTVLENLLVLCVILHSRSLRCRPSYHFIGSLAVADLLGSVIFVYSFVDFHVFHRKDSPNVFLFKLGGVTASFTASVGSLFLTAIDRYISIHRPLAYKRIVTRPKAVVAFCLMWTIAIVIAVLPLLGWNCKKLQSVCSDIFPLIDETYLMFWIGVTSVLLLFIVYAYMYILWKAHSHAVRMIQRGTQKSIIIHTSEDGKVQVTRPDQARMDIRLAKTLVLILVVLIICWGPLLAIMVYDVFGKMNKLIKTVFAFCSMLCLLNSTVNPIIYALRSKDLRHAFRSMFPSCEGTAQPLDNSMGDSDCLHKHANNTASMHRAAESCIKSTVKIAKVTMSVSTDTSAEAL
  
Inhibitor
Name:
BDBM50292327
Synonyms:
CHEMBL241774 | N-(piperidin-1-yl)-3-(4-chlorophenyl)-2-hexyl-1,1-dioxo-1,2-dihydro-1lambda6-1,2,6-thiadiazine-5-carboxamide
Type:
Small organic molecule
Emp. Form.:
C21H29ClN4O3S
Mol. Mass.:
452.998
SMILES:
CCCCCCN1C(=CC(=NS1(=O)=O)C(=O)NN1CCCCC1)c1ccc(Cl)cc1 |c:7,9|
Structure:
Search PDB for entries with ligand similarity: