Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50225227
Substrate
n/a
Meas. Tech.
ChEMBL_451108 (CHEMBL900187)
pH
4.4±n/a
IC50
3160±n/a nM
Comments
extracted
Citation
 Gupta, S; Chhibber, M; Sinha, S; Surolia, A Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. J Med Chem 50:5589-99 (2007) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50225227
Synonyms:
2,4-dichloro-1-(4-(chloromethyl)-2-methoxyphenoxy)benzene | CHEMBL240807
Type:
Small organic molecule
Emp. Form.:
C14H11Cl3O2
Mol. Mass.:
317.595
SMILES:
COc1cc(CCl)ccc1Oc1ccc(Cl)cc1Cl
Structure:
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