Reaction Details Report a problem with these data
Target
Transthyretin
Ligand
BDBM50225217
Substrate
n/a
Meas. Tech.
ChEMBL_451109 (CHEMBL900184)
pH
4.4±n/a
Kd
5.7±n/a nM
Comments
extracted
Citation
 Gupta, S; Chhibber, M; Sinha, S; Surolia, A Design of mechanism-based inhibitors of transthyretin amyloidosis: studies with biphenyl ethers and new structural templates. J Med Chem 50:5589-99 (2007) [PubMed]  Article 
Target
Name:
Transthyretin
Synonyms:
ATTR | PALB | Prealbumin | TBPA | TTHY_HUMAN | TTR | Transthyretin (TTR)
Type:
Enzyme
Mol. Mass.:
15884.31
Organism:
Homo sapiens (Human)
Description:
P02766
Residue:
147
Sequence:
MASHRLLLLCLAGLVFVSEAGPTGTGESKCPLMVKVLDAVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLTTEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAALLSPYSYSTTAVVTNPKE
  
Inhibitor
Name:
BDBM50225217
Synonyms:
5-(chloromethyl)-2-(2,4-dichlorophenoxy)phenol | CHEMBL240805
Type:
Small organic molecule
Emp. Form.:
C13H9Cl3O2
Mol. Mass.:
303.568
SMILES:
Oc1cc(CCl)ccc1Oc1ccc(Cl)cc1Cl
Structure:
Search PDB for entries with ligand similarity: