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Target
Methionine aminopeptidase
Ligand
BDBM50225275
Substrate
n/a
Meas. Tech.
ChEMBL_451278 (CHEMBL901489)
IC50
640±n/a nM
Citation
 Huang, M; Xie, SX; Ma, ZQ; Huang, QQ; Nan, FJ; Ye, QZ Inhibition of monometalated methionine aminopeptidase: inhibitor discovery and crystallographic analysis. J Med Chem 50:5735-42 (2007) [PubMed]  Article 
Target
Name:
Methionine aminopeptidase
Synonyms:
EcMetAP | MAP1_ECOLI | Methionine Aminopeptidase (MAP) | Methionine aminopeptidase | Peptidase M | map
Type:
Enzyme
Mol. Mass.:
29326.96
Organism:
Escherichia coli (strain K12)
Description:
Full-length untagged EcMAP was expressed in E. coli.
Residue:
264
Sequence:
MAISIKTPEDIEKMRVAGRLAAEVLEMIEPYVKPGVSTGELDRICNDYIVNEQHAVSACLGYHGYPKSVCISINEVVCHGIPDDAKLLKDGDIVNIDVTVIKDGFHGDTSKMFIVGKPTIMGERLCRITQESLYLALRMVKPGINLREIGAAIQKFVEAEGFSVVREYCGHGIGRGFHEEPQVLHYDSRETNVVLKPGMTFTIEPMVNAGKKEIRTMKDGWTVKTKDRSLSAQYEHTIVVTDNGCEILTLRKDDTIPAIISHDE
  
Inhibitor
Name:
BDBM50225275
Synonyms:
CHEMBL238659 | H-imidazo[2,1-a]isoquinoline-2-carbohydrazide | IMIDAZO[2,1-A]ISOQUINOLINE-2-CARBOHYDRAZIDE
Type:
Small organic molecule
Emp. Form.:
C12H10N4O
Mol. Mass.:
226.234
SMILES:
NNC(=O)c1cn2ccc3ccccc3c2n1
Structure:
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