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Target
Cruzipain
Ligand
BDBM50225446
Substrate
n/a
Meas. Tech.
ChEMBL_451421 (CHEMBL900556)
IC50
>50000±n/a nM
Citation
 Porcal, W; Hernández, P; Boiani, M; Aguirre, G; Boiani, L; Chidichimo, A; Cazzulo, JJ; Campillo, NE; Paez, JA; Castro, A; Krauth-Siegel, RL; Davies, C; Basombrío, MA; González, M; Cerecetto, H In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives. J Med Chem 50:6004-15 (2007) [PubMed]  Article 
Target
Name:
Cruzipain
Synonyms:
CYSP_TRYCR | Cruzain | Cruzaine | Major cysteine proteinase
Type:
Protein
Mol. Mass.:
49831.41
Organism:
Trypanosoma cruzi
Description:
P25779
Residue:
467
Sequence:
MSGWARALLLAAVLVVMACLVPAATASLHAEETLTSQFAEFKQKHGRVYESAAEEAFRLSVFRENLFLARLHAAANPHATFGVTPFSDLTREEFRSRYHNGAAHFAAAQERARVPVKVEVVGAPAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSEQMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPPCTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGGVMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGSNQCLVKEEASSAVVGGPGPTPEPTTTTTTSAPGPSPSYFVQMSCTDAACIVGCENVTLPTGQCLLTTSGVSAIVTCGAETLTEEVFLTSTHCSGPSVRSSVPLNKCNRLLRGSVEFFCGSSSSGRLADVDRQRRHQPYHSRHRRL
  
Inhibitor
Name:
BDBM50225446
Synonyms:
5(Z)-[2-(phenylsulfonyl)vinyl]benzo[1,2-c]1,2,5-oxadiazole N1-oxide | CHEMBL391827
Type:
Small organic molecule
Emp. Form.:
C14H10N2O4S
Mol. Mass.:
302.305
SMILES:
[O-][n+]1onc2cc(\C=C/S(=O)(=O)c3ccccc3)ccc12
Structure:
Search PDB for entries with ligand similarity: