Reaction Details Report a problem with these data
Target
Melanocortin receptor 4
Ligand
BDBM50225608
Substrate
n/a
Meas. Tech.
ChEMBL_458669 (CHEMBL942952)
Ki
190±n/a nM
Citation
 Chen, CW; Tran, JA; Fleck, BA; Tucci, FC; Jiang, W; Chen, C Synthesis and characterization of trans-4-(4-chlorophenyl)pyrrolidine-3-carboxamides of piperazinecyclohexanes as ligands for the melanocortin-4 receptor. Bioorg Med Chem Lett 17:6825-31 (2007) [PubMed]  Article 
Target
Name:
Melanocortin receptor 4
Synonyms:
MC4-R | MC4R | MC4R_HUMAN | Melanocortin MC4 | Melanocortin receptor 4 (MC-4) | Melanocortin receptor 4 (MC4-R) | Melanocortin receptor 4 (MC4R)
Type:
Enzyme
Mol. Mass.:
36949.50
Organism:
Homo sapiens (Human)
Description:
P32245
Residue:
332
Sequence:
MVNSTHRGMHTSLHLWNRSSYRLHSNASESLGKGYSDGGCYEQLFVSPEVFVTLGVISLLENILVIVAIAKNKNLHSPMYFFICSLAVADMLVSVSNGSETIVITLLNSTDTDAQSFTVNIDNVIDSVICSSLLASICSLLSIAVDRYFTIFYALQYHNIMTVKRVGIIISCIWAACTVSGILFIIYSDSSAVIICLITMFFTMLALMASLYVHMFLMARLHIKRIAVLPGTGAIRQGANMKGAITLTILIGVFVVCWAPFFLHLIFYISCPQNPYCVCFMSHFNLYLILIMCNSIIDPLIYALRSQELRKTFKEIICCYPLGGLCDLSSRY
  
Inhibitor
Name:
BDBM50225608
Synonyms:
1-((3R,4S)-3-(1-(1-((benzylamino)methyl)cyclohexyl)piperazine-4-carbonyl)-4-(4-chlorophenyl)pyrrolidin-1-yl)butan-1-one | CHEMBL251288
Type:
Small organic molecule
Emp. Form.:
C33H45ClN4O2
Mol. Mass.:
565.189
SMILES:
CCCC(=O)N1C[C@@H]([C@H](C1)c1ccc(Cl)cc1)C(=O)N1CCN(CC1)C1(CNCc2ccccc2)CCCCC1
Structure:
Search PDB for entries with ligand similarity: