Target
Histone deacetylase 1
Ligand
BDBM50226116
Substrate
n/a
Meas. Tech.
ChEMBL_451853 (CHEMBL902067)
IC50
100±n/a nM
Citation
 Vaisburg, APaquin, IBernstein, NFrechette, SGaudette, FLeit, SMoradei, ORaeppel, SZhou, NBouchain, GWoo, SHJin, ZGillespie, JWang, JFournel, MYan, PTTrachy-Bourget, MCRobert, MFLu, AYuk, JRahil, JMacleod, ARBesterman, JMLi, ZDelorme, D N-(2-Amino-phenyl)-4-(heteroarylmethyl)-benzamides as new histone deacetylase inhibitors. Bioorg Med Chem Lett 17:6729-33 (2007) [PubMed]  Article 
Target
Name:
Histone deacetylase 1
Synonyms:
Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:
Enzyme
Mol. Mass.:
55090.27
Organism:
Homo sapiens (Human)
Description:
Q13547
Residue:
482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKANAEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVASAVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHGDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAIFKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGGGGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLEKIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEFSDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVKLA
  
Inhibitor
Name:
BDBM50226116
Synonyms:
4-((1-(4-methoxybenzyl)-2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)methyl)-N-(2-aminophenyl)benzamide | CHEMBL241551
Type:
Small organic molecule
Emp. Form.:
C30H26N4O4
Mol. Mass.:
506.5518
SMILES:
COc1ccc(Cn2c3ccccc3c(=O)n(Cc3ccc(cc3)C(=O)Nc3ccccc3N)c2=O)cc1
Structure:
Search PDB for entries with ligand similarity: