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Target
Peptidyl-prolyl cis-trans isomerase FKBP1A
Ligand
BDBM50228110
Substrate
n/a
Meas. Tech.
ChEMBL_452413 (CHEMBL902649)
Kd
39000±n/a nM
Citation
 Stebbins, JL; Zhang, Z; Chen, J; Wu, B; Emdadi, A; Williams, ME; Cashman, J; Pellecchia, M Nuclear magnetic resonance fragment-based identification of novel FKBP12 inhibitors. J Med Chem 50:6607-17 (2007) [PubMed]  Article 
Target
Name:
Peptidyl-prolyl cis-trans isomerase FKBP1A
Synonyms:
12 kDa FK506-binding protein | 12 kDa FKBP | FK506-binding protein 1A | FK506-binding protein 1A (FKBP12) | FKB1A_HUMAN | FKBP-12 | FKBP-1A | FKBP1 | FKBP12 | FKBP1A | Immunophilin FKBP12 | PPIase | PPIase FKBP1A | Peptidyl-prolyl cis-trans isomerase (FKBP) | Rotamase | RyR1/FKBP12 | mTOR/FKBP12A/FKBP12B
Type:
Isomerase
Mol. Mass.:
11953.09
Organism:
Homo sapiens (Human)
Description:
P62942
Residue:
108
Sequence:
MGVQVETISPGDGRTFPKRGQTCVVHYTGMLEDGKKFDSSRDRNKPFKFMLGKQEVIRGWEEGVAQMSVGQRAKLTISPDYAYGATGHPGIIPPHATLVFDVELLKLE
  
Inhibitor
Name:
BDBM50228110
Synonyms:
3-((4,5-dihydroisoxazol-3-yl)methylthio)-5-methyl-4-phenyl-4H-1,2,4-triazole | CHEMBL237815
Type:
Small organic molecule
Emp. Form.:
C13H14N4OS
Mol. Mass.:
274.341
SMILES:
Cc1nnc(SCC2=NOCC2)n1-c1ccccc1 |t:7|
Structure:
Search PDB for entries with ligand similarity: