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Target
Alpha-amylase
Ligand
BDBM50231672
Substrate
n/a
Meas. Tech.
ChEMBL_462051 (CHEMBL945826)
IC50
6070±n/a nM
Citation
Zhou, Y; Zhao, Y; O' Boyle, KM; Murphy, PV Hybrid angiogenesis inhibitors: synthesis and biological evaluation of bifunctional compounds based on 1-deoxynojirimycin and aryl-1,2,3-triazoles. Bioorg Med Chem Lett 18:954-8 (2008) [PubMed] Article
More Info.:
Target
Name:
Alpha-amylase
Synonyms:
Alpha-glucosidase
Type:
PROTEIN
Mol. Mass.:
65231.69
Organism:
Bacillus stearothermophilus
Description:
ChEMBL_740884
Residue:
555
Sequence:
MKKTWWKEGVAYQIYPRSFMDANGDGIGDLRGIIEKLDYLVELGVDIVWICPIYRSPNADNGYDISDYYAIMDEFGTMDDFDELLAQAHRRGLKIILDLVINHTSDEHPWFIESRSSRDNPKRDWYIWRDGKDGREPNNWESIFGGSAWQYDERTGQYYLHLFDVKQPDLNWENSEVRQALYDMINWWLDKGIDGFRIDAISHIKKKPGLPDLPNPKGLKYVPSFAAHMNQPGIMEYLRELKEQTFARYDIMTVGEANGVTVDEAEQWVGEENGVFHMIFQFEHLGLWKRKADGSIDVRRLKRTLTKWQKGLENRGWNALFLENHDLPRSVSTWGNDREYWAESAKALGALYFFMQGTPFIYQGQEIGMTNVQFSDIRDYRDVAALRLYELERANGRTHEEVMKIIWKTGRDNSRTPMQWSDAPNAGFTTGTPWIKVNENYRTINVEAERRDPNSVWSFYRQMIQLRKANELFVYGAYDLLLENHPSIYAYTRTLGRDRALIIVNVSDRPSLYRYDGFRLQSSDLALSNYPVRPHKNATRFKLKPYEARVYIWKE
Inhibitor
Name:
BDBM50231672
Synonyms:
(2R,3R,4R,5S)-1-(4-(3-(1H-1,2,3-triazol-4-yl)phenoxy)butyl)-2-(hydroxymethyl)piperidine-3,4,5-triol | (2R,3R,4R,5S)-1-(4-(3-(3H-1,2,3-triazol-4-yl)phenoxy)butyl)-2-(hydroxymethyl)piperidine-3,4,5-triol | CHEMBL401628
Type:
Small organic molecule
Emp. Form.:
C18H26N4O5
Mol. Mass.:
378.4228
SMILES:
OC[C@@H]1[C@@H](O)[C@H](O)[C@@H](O)CN1CCCCOc1cccc(c1)-c1c[nH]nn1 |r|